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Details on Person SGMS1 transfers phosphocholine onto ceramide

Class:Id	Reaction:429798
_displayName	SGMS1 transfers phosphocholine onto ceramide
_doRelease	TRUE
_timestamp	2025-06-16 19:32:50
authored	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
catalystActivity	[CatalystActivity:429784] sphingomyelin synthase activity of SGMS1 [Golgi membrane]
compartment	[Compartment:20699] Golgi membrane
created	[InstanceEdit:429791] D'Eustachio, P, 2009-07-21
edited	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
input	[SimpleEntity:429785] PC [Golgi membrane] [SimpleEntity:428270] CERA [Golgi membrane]
literatureReference	[LiteratureReference:429792] Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells [LiteratureReference:429778] Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells [LiteratureReference:429797] Identification of a family of animal sphingomyelin synthases [LiteratureReference:435217] Evidence for a new biosynthetic pathway of sphingomyelin in SV 40 transformed mouse cells [LiteratureReference:435213] The enzymatic formation of sphingomyelin from ceramide and lecithin in mouse liver [LiteratureReference:9843208] The sphingomyelin synthase family: proteins, diseases, and inhibitors
modified	[InstanceEdit:429809] D'Eustachio, P, 2009-07-21 [InstanceEdit:433040] D'Eustachio, P, 2009-08-20 [InstanceEdit:435211] D'Eustachio, P, 2009-09-07 [InstanceEdit:446904] D'Eustachio, P, 2009-11-18 [InstanceEdit:1660664] Jassal, B, 2011-10-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9841785] Stephan, Ralf, 2023-08-12 [InstanceEdit:9843209] Stephan, Ralf, 2023-09-05 [InstanceEdit:9851294] Stephan, Ralf, 2023-10-20 [InstanceEdit:9851343] Stephan, Ralf, 2023-10-24 [InstanceEdit:9956913] D'Eustachio, Peter, 2025-06-16
name	SGMS1 transfers phosphocholine onto ceramide phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]
output	[SimpleEntity:429789] SPHM [Golgi membrane] [SimpleEntity:1524057] DAG [Golgi membrane]
precedingEvent	[Reaction:9956909] CERT1-2 transfers CERA from the ER membrane to the Golgi membrane [Homo sapiens] [Reaction:429730] PPM1L dephosphorylates multiphospho-CERT1-2 [Homo sapiens]
releaseDate	2009-09-30
reviewed	[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18 [InstanceEdit:433039] Jassal, B, 2009-08-20 [InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104569] R-HSA-429798.5
summation	[Summation:429803] SGMS1 (sphingomyelin synthase 1) associated with the membran...
(hasEvent)	[Pathway:1660661] Sphingolipid de novo biosynthesis [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9853202] Update Tracker - [Reaction:429798] SGMS1 transfers phosphocholine onto ceramide - v87:[addLiteratureReference, add_removeOutput, modifyText]
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