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Details on Person SGMS2 transfers phosphocholine onto ceramide
Class:Id Reaction:429786 _displayName SGMS2 transfers phosphocholine onto ceramide _doRelease TRUE _timestamp 2023-10-24 07:55:01 authored [InstanceEdit:433041] D'Eustachio, P, 2009-08-20 catalystActivity [CatalystActivity:429800] sphingomyelin synthase activity of 2xPalmC-SGMS2 [plasma membrane] compartment [Compartment:876] plasma membrane created [InstanceEdit:429791] D'Eustachio, P, 2009-07-21 edited [InstanceEdit:433041] D'Eustachio, P, 2009-08-20 input [SimpleEntity:429802] PC [plasma membrane] [SimpleEntity:429807] CERA [plasma membrane] literatureReference [LiteratureReference:429792] Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells [LiteratureReference:429797] Identification of a family of animal sphingomyelin synthases [LiteratureReference:429779] Sphingomyelin synthase 2 is palmitoylated at the COOH-terminal tail, which is involved in its localization in plasma membranes [LiteratureReference:435217] Evidence for a new biosynthetic pathway of sphingomyelin in SV 40 transformed mouse cells [LiteratureReference:435213] The enzymatic formation of sphingomyelin from ceramide and lecithin in mouse liver [LiteratureReference:435218] SMS overexpression and knockdown: impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis [LiteratureReference:9843208] The sphingomyelin synthase family: proteins, diseases, and inhibitors modified [InstanceEdit:429809] D'Eustachio, P, 2009-07-21 [InstanceEdit:433040] D'Eustachio, P, 2009-08-20 [InstanceEdit:435211] D'Eustachio, P, 2009-09-07 [InstanceEdit:446904] D'Eustachio, P, 2009-11-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9841793] Stephan, Ralf, 2023-08-12 [InstanceEdit:9843209] Stephan, Ralf, 2023-09-05 [InstanceEdit:9851294] Stephan, Ralf, 2023-10-20 [InstanceEdit:9851343] Stephan, Ralf, 2023-10-24 name SGMS2 transfers phosphocholine onto ceramide output [SimpleEntity:9843210] SPHM [plasma membrane] [SimpleEntity:114519] DAG [plasma membrane] precedingEvent
releaseDate 2009-09-30 reviewed [InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18 [InstanceEdit:433039] Jassal, B, 2009-08-20 [InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:1104571] R-HSA-429786.4 summation [Summation:429790] SGMS2 (sphingomyelin synthase 2) catalyzes the reversible re... (hasEvent) [Pathway:1660661] Sphingolipid de novo biosynthesis [Homo sapiens] (precedingEvent) [Reaction:1606273] SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) [Homo sapiens] [Reaction:1640164] ENPP7 hydrolyzes sphingomyelin [Homo sapiens] (updatedInstance) [_UpdateTracker:9853267] Update Tracker - [Reaction:429786] SGMS2 transfers phosphocholine onto ceramide - v87:[addLiteratureReference, add_removeOutput, modifyText]
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