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Details on Person PPM1L dephosphorylates multiphospho-CERT1-2

Class:IdReaction:429730
_displayNamePPM1L dephosphorylates multiphospho-CERT1-2
_doReleaseTRUE
_timestamp2025-08-13 19:23:50
authored[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
catalystActivity[CatalystActivity:429724] protein serine/threonine phosphatase activity of PPM1L:VAPA/B dimer [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:429733] D'Eustachio, P, 2009-07-20
crossReference[DatabaseIdentifier:9857130] RHEA:20630
[DatabaseIdentifier:9857132] RHEA:47005
edited[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
input[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:29356] H2O [cytosol]
[Complex:429703] PPM1L:VAPA/B dimer [endoplasmic reticulum membrane] [Homo sapiens]
[EntityWithAccessionedSequence:429695] p-S,S132,T-CERT1-2 [cytosol] [Homo sapiens]
internalReviewed[InstanceEdit:9956926] D'Eustachio, Peter, 2025-06-16
literatureReference[LiteratureReference:429720] Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes
[LiteratureReference:9843187] Structure, functions and regulation of CERT, a lipid-transfer protein for the delivery of ceramide at the ER-Golgi membrane contact sites
modified[InstanceEdit:429734] D'Eustachio, P, 2009-07-20
[InstanceEdit:433040] D'Eustachio, P, 2009-08-20
[InstanceEdit:446904] D'Eustachio, P, 2009-11-18
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:1660664] Jassal, B, 2011-10-14
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9841785] Stephan, Ralf, 2023-08-12
[InstanceEdit:9843191] Stephan, Ralf, 2023-09-02
[InstanceEdit:9851294] Stephan, Ralf, 2023-10-20
[InstanceEdit:9851343] Stephan, Ralf, 2023-10-24
[InstanceEdit:9956913] D'Eustachio, Peter, 2025-06-16
[InstanceEdit:9956927] D'Eustachio, Peter, 2025-06-16
[InstanceEdit:9963234] D'Eustachio, Peter, 2025-08-13
namePPM1L dephosphorylates multiphospho-CERT1-2
O-phospho-L-seryl/threonyl-(protein) + H2O => L-seryl/threonyl-(protein) + phosphate
output[Complex:429672] CERT1-2:PPM1L:VAPA/B dimer [endoplasmic reticulum membrane] [Homo sapiens]
[SimpleEntity:29372] Pi [cytosol]
[SimpleEntity:29372] Pi [cytosol]
[SimpleEntity:29372] Pi [cytosol]
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2009-09-30
reviewed[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18
[InstanceEdit:433039] Jassal, B, 2009-08-20
[InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
[InstanceEdit:9963235] Hill, David P, 2025-08-13
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104239] R-HSA-429730.5
structureModified[InstanceEdit:9956913] D'Eustachio, Peter, 2025-06-16
summation[Summation:429731] Multiphospho-CERT (ceramide transfer protein) associates wit...
(hasEvent)[Pathway:1660661] Sphingolipid de novo biosynthesis [Homo sapiens]
(precedingEvent)[Reaction:9956909] CERT1-2 transfers CERA from the ER membrane to the Golgi membrane [Homo sapiens]
(replacementInstances)[_Deleted:9956922] Deletion of instance: 429732
(updatedInstance)[_UpdateTracker:9782047] Update Tracker - [Reaction:429730] multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate - v59:[modifyText]
[_UpdateTracker:9783252] Update Tracker - [Reaction:429730] multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate - v57:[modifyText]
[_UpdateTracker:9784701] Update Tracker - [Reaction:429730] multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate - v53:[modifyText]
[_UpdateTracker:9789686] Update Tracker - [Reaction:429730] multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate - v37:[modifyText]
[_UpdateTracker:9853288] Update Tracker - [Reaction:429730] PPM1L dephosphorylates multiphospho-CERT1-2 - v87:[addLiteratureReference, modifyText]
[_UpdateTracker:9964728] Update Tracker - [Reaction:429730] PPM1L dephosphorylates multiphospho-CERT1-2 - v94:[add_removeInput, modifyText]
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