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Details on Person PRKD1,2,3 phosphorylates CERT1-2

Class:Id	Reaction:429698
_displayName	PRKD1,2,3 phosphorylates CERT1-2
_doRelease	TRUE
_timestamp	2025-06-16 19:32:46
authored	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
catalystActivity	[CatalystActivity:8874351] diacylglycerol-dependent, calcium-independent serine/threonine kinase activity of PRKD1,2,3 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:429702] D'Eustachio, P, 2009-07-18
edited	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
input	[SimpleEntity:113592] ATP [cytosol] [EntityWithAccessionedSequence:429712] CERT1-2 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:429685] Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein [LiteratureReference:9843183] Hyperosmotic Stress Induces Phosphorylation of CERT and Enhances Its Tethering throughout the Endoplasmic Reticulum [LiteratureReference:9843187] Structure, functions and regulation of CERT, a lipid-transfer protein for the delivery of ceramide at the ER-Golgi membrane contact sites [LiteratureReference:9843184] Phosphoregulation of the ceramide transport protein CERT at serine 315 in the interaction with VAMP-associated protein (VAP) for inter-organelle trafficking of ceramide in mammalian cells [LiteratureReference:9843190] Integration of non-vesicular and vesicular transport processes at the Golgi complex by the PKD-CERT network
modified	[InstanceEdit:429723] D'Eustachio, P, 2009-07-18 [InstanceEdit:433040] D'Eustachio, P, 2009-08-20 [InstanceEdit:446904] D'Eustachio, P, 2009-11-18 [InstanceEdit:1660664] Jassal, B, 2011-10-14 [InstanceEdit:8877166] Jassal, Bijay, 2016-06-21 [InstanceEdit:8879087] Jassal, Bijay, 2016-07-15 [InstanceEdit:9753297] Jassal, Bijay, 2021-09-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9841785] Stephan, Ralf, 2023-08-12 [InstanceEdit:9843188] Stephan, Ralf, 2023-09-02 [InstanceEdit:9843191] Stephan, Ralf, 2023-09-02 [InstanceEdit:9845639] Stephan, Ralf, 2023-10-07 [InstanceEdit:9851294] Stephan, Ralf, 2023-10-20 [InstanceEdit:9851343] Stephan, Ralf, 2023-10-24 [InstanceEdit:9956913] D'Eustachio, Peter, 2025-06-16
name	PRKD1,2,3 phosphorylates CERT1-2 CERT + ATP => monophospho-CERT + ADP
output	[SimpleEntity:29370] ADP [cytosol] [EntityWithAccessionedSequence:429704] p-S132-CERT1-2 [cytosol] [Homo sapiens] [SimpleEntity:70106] H+ [cytosol]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2009-09-30
reviewed	[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18 [InstanceEdit:433039] Jassal, B, 2009-08-20 [InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105937] R-HSA-429698.7
structureModified	[InstanceEdit:9845639] Stephan, Ralf, 2023-10-07
summation	[Summation:429690] Cytosolic PRKD1, 2, and 3 (protein kinase D1, D2, and D3) ca...
(hasEvent)	[Pathway:1660661] Sphingolipid de novo biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:429714] CSNK1G2 phosphorylates p-CERT1-2 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775465] Update Tracker - [Reaction:429698] PRKD1,2,3 phosphorylates CERT1-2 - v79:[modifyText] [_UpdateTracker:9782987] Update Tracker - [Reaction:429698] PRKD1,2,3 phosphorylates CERT1-2 - v58:[add_removeCatalystActivity, modifyText] [_UpdateTracker:9783018] Update Tracker - [Reaction:429698] PRKD1,2,3 phosphorylates CERT1-2 - v57:[modifyText] [_UpdateTracker:9784841] Update Tracker - [Reaction:429698] PRKD1,2,3 phosphorylates CERT1-2 - v53:[modifyText] [_UpdateTracker:9789874] Update Tracker - [Reaction:429698] PRKD1,2,3 phosphorylates CERT1-2 - v37:[modifyText] [_UpdateTracker:9853190] Update Tracker - [Reaction:429698] PRKD1,2,3 phosphorylates CERT1-2 - v87:[addLiteratureReference, addOutput, modifyText]
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