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Details on Person Cytosolic PRKD1, 2, and 3 (protein kinase D1, D2, and D3) ca...
| Class:Id | Summation:429690 |
|---|---|
| _displayName | Cytosolic PRKD1, 2, and 3 (protein kinase D1, D2, and D3) ca... |
| _timestamp | 2023-09-02 09:01:47 |
| created | [InstanceEdit:429702] D'Eustachio, P, 2009-07-18 |
| modified | [InstanceEdit:429723] D'Eustachio, P, 2009-07-18 [InstanceEdit:8877169] Jassal, Bijay, 2016-06-21 [InstanceEdit:8879088] Jassal, Bijay, 2016-07-15 [InstanceEdit:9753298] Jassal, Bijay, 2021-09-06 [InstanceEdit:9843188] Stephan, Ralf, 2023-09-02 [InstanceEdit:9843191] Stephan, Ralf, 2023-09-02 |
| text | Cytosolic PRKD1, 2, and 3 (protein kinase D1, D2, and D3) catalyze the phosphorylation of serine residue 132 of isoform 2 of ceramide transfer protein (CERT1-2, aka COL4A3BP-2). Protein kinase D (PRKD) is a crucial regulator of secretory transport at the trans-Golgi network (TGN). Phosphorylation of COL4A3BP-2 reduces its ceramide transfer activity. PRKDs may, therefore, act as regulators of lipid homeostasis (Fugmann et al., 2007; Kumagai et al., 2014; Shimasaki et al., 2022; reviewed by Olayioye & Hausser, 2011; Kumagai & Hanada, 2019). |
| (summation) | [Reaction:429698] PRKD1,2,3 phosphorylates CERT1-2 [Homo sapiens] |
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No pathways have been reviewed or authored by Cytosolic PRKD1, 2, and 3 (protein kinase D1, D2, and D3) ca... (429690)
