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Details on Person CERT1-2 (ceramide transfer protein, isoform 2), associated w...
| Class:Id | Summation:429671 |
|---|---|
| _displayName | CERT1-2 (ceramide transfer protein, isoform 2), associated w... |
| _timestamp | 2023-09-04 09:07:54 |
| created | [InstanceEdit:429702] D'Eustachio, P, 2009-07-18 |
| modified | [InstanceEdit:429723] D'Eustachio, P, 2009-07-18 [InstanceEdit:9753296] Jassal, Bijay, 2021-09-06 [InstanceEdit:9843203] Stephan, Ralf, 2023-09-04 |
| text | CERT1-2 (ceramide transfer protein, isoform 2), associated with the cytosolic face of the endoplasmic reticulum (ER) in a complex with VAPA or VAPB (VAMP-associated proteins A or B) (Kawano et al. 2006) and PPM1L (protein phosphatase 1-like) (Saito et al. 2008), can bridge the gap between the ER and the Golgi apparatus via its PH domain and transfer a molecule of ceramide extracted from the ER membrane to the Golgi at the ER-Golgi membrane contact sites (MCS) (Hanada et al. 2003; Saito et al. 2008). CERT1-2-mediated ceramide transfer is positively regulated by OSBP (oxysterol binding protein), apparently through accumulation of phosphatidylinositol 4-phosphate (PI-4P) at MCS (Perry and Ridgway 2006; Goto et al., 2016). Non-vesicular transport of ceramide from endoplasmic reticulum to Golgi membranes is essential for cellular lipid homeostasis (reviewed by Olaiyoye et al., 2012; Kumagai & Hanada, 2019). |
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No pathways have been reviewed or authored by CERT1-2 (ceramide transfer protein, isoform 2), associated w... (429671)
