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Details on Person SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol

Class:Id	Reaction:429663
_displayName	SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol
_doRelease	TRUE
_timestamp	2025-06-13 15:24:34
authored	[InstanceEdit:429634] Jassal, Bijay, 2009-07-17
catalystActivity	[CatalystActivity:429638] myo-inositol:sodium symporter activity of SLC5A3 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:429634] Jassal, Bijay, 2009-07-17
crossReference	[DatabaseIdentifier:9956752] RHEA:72988
edited	[InstanceEdit:429634] Jassal, Bijay, 2009-07-17
input	[SimpleEntity:429130] Ins [extracellular region] [SimpleEntity:74113] Na+ [extracellular region] [SimpleEntity:74113] Na+ [extracellular region]
literatureReference	[LiteratureReference:429654] The human osmoregulatory Na+/myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21 [LiteratureReference:8981472] Kinetics and specificity of the renal Na+/myo-inositol cotransporter expressed in Xenopus oocytes
modified	[InstanceEdit:433652] Jassal, Bijay, 2009-08-24 [InstanceEdit:8981471] D'Eustachio, Peter, 2017-03-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9956750] Stephan, Ralf, 2025-06-13
name	SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol Co-transport (influx) of myo-inositol and two Na+ ions by SMIT
output	[SimpleEntity:426910] Ins [cytosol] [SimpleEntity:83910] Na+ [cytosol] [SimpleEntity:83910] Na+ [cytosol]
releaseDate	2009-09-30
reviewed	[InstanceEdit:433651] He, L, 2009-08-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104326] R-HSA-429663.4
summation	[Summation:429649] The human SLC5A3 gene encodes a Na+/myo-inositol (Ins) trans...
(hasEvent)	[Pathway:429593] Inositol transporters [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781154] Update Tracker - [Reaction:429663] SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol - v61:[addLiteratureReference, modifyText]
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