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Details on Person SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol

Class:IdReaction:429613
_displayNameSLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol
_doReleaseTRUE
_timestamp2025-08-14 08:00:53
authored[InstanceEdit:429634] Jassal, Bijay, 2009-07-17
catalystActivity[CatalystActivity:429647] D-glucose:sodium symporter activity of SLC5As, NAGLT1 [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:984] extracellular region
created[InstanceEdit:429634] Jassal, Bijay, 2009-07-17
edited[InstanceEdit:429634] Jassal, Bijay, 2009-07-17
input[SimpleEntity:70115] Glc [extracellular region]
[SimpleEntity:74113] Na+ [extracellular region]
literatureReference[LiteratureReference:429617] Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter
[LiteratureReference:429604] Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria
[LiteratureReference:5336451] Cloning and characterization of a novel Na+-dependent glucose transporter (NaGLT1) in rat kidney
modified[InstanceEdit:433652] Jassal, Bijay, 2009-08-24
[InstanceEdit:5336462] Jassal, Bijay, 2014-03-03
[InstanceEdit:5358715] Jassal, Bijay, 2014-04-03
[InstanceEdit:5656371] Jassal, Bijay, 2014-12-12
[InstanceEdit:5658180] Jassal, Bijay, 2014-12-18
[InstanceEdit:5674209] Jassal, Bijay, 2015-02-11
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9963472] Stephan, Ralf, 2025-08-14
nameSLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol
Co-transport (influx) of glucose and Na+ ions by SLC5As, NAGLT1
negativePrecedingEvent[NegativePrecedingEvent:9963476] Futile Cycle: GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region
[NegativePrecedingEvent:9963435] Futile Cycle: SLC50A1 transports Glc from cytosol to extracellular region
output[SimpleEntity:70113] Glc [cytosol]
[SimpleEntity:83910] Na+ [cytosol]
releaseDate2009-09-30
reviewed[InstanceEdit:433651] He, L, 2009-08-24
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:5674206] Jassal, Bijay, 2015-02-11
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105225] R-HSA-429613.3
summation[Summation:429582] The human gene SLC5A2 encodes a sodium-dependent glucose tra...
(hasEvent)[Pathway:189200] Cellular hexose transport [Homo sapiens]
(normalReaction)[FailedReaction:5656356] Defective SLC5A1 does not cotransport Glc and Na+ [Homo sapiens]
[FailedReaction:5658163] Defective SLC5A2 does not cotransport Glc and Na+ from extracellular region to cytosol [Homo sapiens]
(precedingEvent)[NegativePrecedingEvent:9963443] Futile Cycle: SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol
[NegativePrecedingEvent:9963467] Futile Cycle: SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol
(updatedInstance)[_UpdateTracker:9784539] Update Tracker - [Reaction:429613] SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol - v54:[modifyText]
[_UpdateTracker:9785118] Update Tracker - [Reaction:429613] SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol - v52:[modifyText]
[_UpdateTracker:9786628] Update Tracker - [Reaction:429613] SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol - v49:[addLiteratureReference, modifyText]
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