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Details on Person SLC5A5 cotransports Na+ with I- from extracellular region to cytosol

Class:Id	Reaction:429591
_displayName	SLC5A5 cotransports Na+ with I- from extracellular region to cytosol
_doRelease	TRUE
_timestamp	2025-08-13 18:01:05
authored	[InstanceEdit:429634] Jassal, Bijay, 2009-07-17
catalystActivity	[CatalystActivity:429651] sodium:iodide symporter activity of SLC5A5 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:429634] Jassal, Bijay, 2009-07-17
edited	[InstanceEdit:429634] Jassal, Bijay, 2009-07-17
input	[SimpleEntity:74113] Na+ [extracellular region] [SimpleEntity:209818] I- [extracellular region]
literatureReference	[LiteratureReference:350105] Cloning of the human sodium lodide symporter [LiteratureReference:429577] Congenital hypothyroidism caused by a mutation in the Na+/I- symporter
modified	[InstanceEdit:429759] Jassal, Bijay, 2009-07-21 [InstanceEdit:433652] Jassal, Bijay, 2009-08-24 [InstanceEdit:1614621] Jassal, Bijay, 2011-09-29 [InstanceEdit:5658180] Jassal, Bijay, 2014-12-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9963189] Stephan, Ralf, 2025-08-13
name	SLC5A5 cotransports Na+ with I- from extracellular region to cytosol Na+/I- cotransport (influx) by the Na+/I- symporter
negativePrecedingEvent	[NegativePrecedingEvent:9963167] Incorrect Order: SLC26A4 exports I- to follicular lumen
output	[SimpleEntity:209785] I- [cytosol] [SimpleEntity:83910] Na+ [cytosol]
precedingEvent	[Reaction:429767] Passive I- efflux mediated by SLC5A8 [Homo sapiens] [Reaction:429591] SLC5A5 cotransports Na+ with I- from extracellular region to cytosol [Homo sapiens]
releaseDate	2009-09-30
reviewed	[InstanceEdit:433651] He, L, 2009-08-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105302] R-HSA-429591.3
summation	[Summation:429580] Human SLC5A5 encodes a Na+/I- symporter, NIS (Smanik et al. ...
(hasEvent)	[Pathway:9958790] SLC-mediated transport of inorganic anions [Homo sapiens]
(normalReaction)	[FailedReaction:5658195] Defective SLC5A5 does not cotransport Na+ with I- from extracellular region to cytosol [Homo sapiens]
(precedingEvent)	[Reaction:429767] Passive I- efflux mediated by SLC5A8 [Homo sapiens] [Reaction:5627802] SLC26A4 exports I- to follicular lumen [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785345] Update Tracker - [Reaction:429591] SLC5A5 cotransports Na+ with I- from extracellular region to cytosol - v52:[modifyText]
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