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Details on Person The human gene SLC5A2 encodes a sodium-dependent glucose tra...
| Class:Id | Summation:429582 |
|---|---|
| _displayName | The human gene SLC5A2 encodes a sodium-dependent glucose tra... |
| _timestamp | 2015-08-04 13:01:15 |
| created | [InstanceEdit:429634] Jassal, Bijay, 2009-07-17 |
| modified | [InstanceEdit:5336462] Jassal, Bijay, 2014-03-03 [InstanceEdit:5362135] Jassal, Bijay, 2014-04-14 [InstanceEdit:5658180] Jassal, Bijay, 2014-12-18 [InstanceEdit:5669285] D'Eustachio, Peter, 2015-01-30 [InstanceEdit:5673780] Jassal, Bijay, 2015-02-10 [InstanceEdit:6789777] Jassal, Bijay, 2015-08-04 |
| text | The human gene SLC5A2 encodes a sodium-dependent glucose transporter, SGLT2 (Wells et al. 1992). SLC5A2 is expressed in many tissues but primarily in the kidney, specifically the renal proximal tubules (S1 and S2 segments). It is a low affinity, high capacity transporter of glucose across the apical membrane, with co-transport of Na+ ions in a 1:1 ratio. Unlike SGLT1, it doesn't transport galactose. SLC5A2 is the main transporter of glucose in the kidney, responsible for approximately 98% of glucose reabsorption (remainder by SGLT1). Defects in SLC5A2 are the cause of renal glucosuria (GLYS1), an autosomal recessive renal tubular disorder (Calado et al. 2004). A separate sodium dependent glucose transporter NAGLT1, was identified in the multifacilitator superfamily (MFS) and could be a transporter of glucose in kidney proximal tubules. Its rat orthologue, Naglt1, has been shown to mediate tubular reabsorption of glucose (Horiba et al. 2003). By similarity, SLC5A1, 4 and 9 are predicted proteins that transport glucose in a Na+-dependent manner. |
| (summation) | [Reaction:429613] SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol [Homo sapiens] |
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