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Details on Person SLP-76 stimulates PLC gamma 2

Class:IdBlackBoxEvent:429497
_displayNameSLP-76 stimulates PLC gamma 2
_doReleaseTRUE
_timestamp2017-12-06 18:06:22
authored[InstanceEdit:425201] Akkerman, JW, 2009-06-03
compartment[Compartment:876] plasma membrane
created[InstanceEdit:429489] Jupe, S, 2009-07-16
edited[InstanceEdit:445674] Jupe, S, 2009-11-03
input[EntityWithAccessionedSequence:114601] PLCG2 [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:429488] Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets
[LiteratureReference:429494] Integrin alpha IIb beta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow. Involvement of phospholipase C gamma 2
[LiteratureReference:429495] Signaling role for phospholipase C gamma 2 in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR gamma chain and Fc gamma RIIA
modified[InstanceEdit:430178] Jupe, S, 2009-08-04
[InstanceEdit:432301] Jupe, S, 2009-08-13
[InstanceEdit:434979] Jupe, S, 2009-09-04
[InstanceEdit:445664] Jupe, S, 2009-11-02
[InstanceEdit:446293] Jupe, S, 2009-11-12
[InstanceEdit:453258] Jupe, S, 2010-01-20
[InstanceEdit:481043] Jupe, S, 2010-01-27
[InstanceEdit:9032143] Orlic-Milacic, Marija, 2017-12-06
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameSLP-76 stimulates PLC gamma 2
output[EntityWithAccessionedSequence:114602] p-PLCG2 [plasma membrane] [Homo sapiens]
precedingEvent
regulatedBy[PositiveRegulation:9032140] Positive regulation by 'p-Y113,128,145-LCP2 [cytosol]'
regulationReference[RegulationReference:9642267] Positive regulation by 'p-Y113,128,145-LCP2 [cytosol]' Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets
releaseDate2009-12-15
reviewed[InstanceEdit:445650] Poole, AW, 2009-11-02
[InstanceEdit:445653] Jones, ML, 2009-11-02
[InstanceEdit:445649] Harper, MT, 2009-11-02
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105495] R-HSA-429497.5
summation[Summation:429492] SLP-76 has a well-established role in recruitment of PLC gam...
(hasEvent)[Pathway:114604] GPVI-mediated activation cascade [Homo sapiens]
(precedingEvent)[Reaction:114689] PLC gamma 2-mediated PIP2 hydrolysis [Homo sapiens]
(updatedInstance)[_UpdateTracker:9779855] Update Tracker - [BlackBoxEvent:429497] SLP-76 stimulates PLC gamma 2 - v64:[addRegulator, removeInput, removeOutput]
[_UpdateTracker:9791211] Update Tracker - [BlackBoxEvent:429497] SLP-76 stimulates PLC gamma 2 - v32:[add_removeInput, add_removeOutput]
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No pathways have been reviewed or authored by SLP-76 stimulates PLC gamma 2 (429497)
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