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Details on Person Syk activation leads to SLP-76 activation

Class:IdReaction:429449
_displayNameSyk activation leads to SLP-76 activation
_doReleaseTRUE
_timestamp2017-12-08 14:47:01
authored[InstanceEdit:425201] Akkerman, JW, 2009-06-03
catalystActivity[CatalystActivity:9032137] protein tyrosine kinase activity of p-Y348-SYK [cytosol]
compartment[Compartment:876] plasma membrane
created[InstanceEdit:429457] Jupe, S, 2009-07-15
edited[InstanceEdit:445674] Jupe, S, 2009-11-03
[InstanceEdit:9032138] Orlic-Milacic, Marija, 2017-12-06
input[EntityWithAccessionedSequence:202306] LCP2 [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
literatureReference[LiteratureReference:429454] Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets
[LiteratureReference:9032127] Phosphatidylinositol-3-kinase-dependent phosphorylation of SLP-76 by the lymphoma-associated ITK-SYK fusion-protein
[LiteratureReference:9032128] Differential Requirements for Src-Family Kinases in SYK or ZAP70-Mediated SLP-76 Phosphorylation in Lymphocytes
[LiteratureReference:9032249] Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation
modified[InstanceEdit:430150] Jupe, S, 2009-07-31
[InstanceEdit:430210] Jupe, S, 2009-08-04
[InstanceEdit:432301] Jupe, S, 2009-08-13
[InstanceEdit:434979] Jupe, S, 2009-09-04
[InstanceEdit:445654] Jupe, S, 2009-11-02
[InstanceEdit:446293] Jupe, S, 2009-11-12
[InstanceEdit:453265] Jupe, S, 2010-01-20
[InstanceEdit:481043] Jupe, S, 2010-01-27
[InstanceEdit:9032138] Orlic-Milacic, Marija, 2017-12-06
[InstanceEdit:9032139] Orlic-Milacic, Marija, 2017-12-06
[InstanceEdit:9032253] Orlic-Milacic, Marija, 2017-12-08
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameSyk activation leads to SLP-76 activation
output[EntityWithAccessionedSequence:202175] p-Y113,128,145-LCP2 [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2009-12-15
reviewed[InstanceEdit:445650] Poole, AW, 2009-11-02
[InstanceEdit:445653] Jones, ML, 2009-11-02
[InstanceEdit:445649] Harper, MT, 2009-11-02
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:9032138] Orlic-Milacic, Marija, 2017-12-06
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105226] R-HSA-429449.3
summation[Summation:429448] Stimulation of platelets with collagen-related peptide leads...
(hasEvent)[Pathway:114604] GPVI-mediated activation cascade [Homo sapiens]
(precedingEvent)[BlackBoxEvent:429497] SLP-76 stimulates PLC gamma 2 [Homo sapiens]
[Reaction:430158] p-SLP-76 binds VAV [Homo sapiens]
[Reaction:430190] p-SLP-76 binds NCK [Homo sapiens]
(updatedInstance)[_UpdateTracker:9779895] Update Tracker - [Reaction:429449] Syk activation leads to SLP-76 activation - v64:[addCatalystActivity, addLiteratureReference, modifyText, removeInput, removeOutput]
[_UpdateTracker:9790903] Update Tracker - [Reaction:429449] Syk activation leads to SLP-76 activation - v32:[add_removeInput, add_removeOutput, modifyText]
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