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Details on Person Integrin alphaIIb beta3 'outside-in' signalling involves mul...
| Class:Id | Summation:429411 |
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| _displayName | Integrin alphaIIb beta3 'outside-in' signalling involves mul... |
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| _timestamp | 2010-09-02 12:12:47 |
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| created | [InstanceEdit:429421] Jupe, S, 2009-07-15 |
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| literatureReference | [LiteratureReference:429419] The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains
[LiteratureReference:429426] Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton
[LiteratureReference:429410] Involvement of Src kinases and PLCgamma2 in clot retraction
[LiteratureReference:377578] Integrins: dynamic scaffolds for adhesion and signaling in platelets |
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| modified | [InstanceEdit:434994] Jupe, S, 2009-09-04
[InstanceEdit:434995] Jupe, S, 2009-09-04
[InstanceEdit:939908] Jupe, S, 2010-09-02 |
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| text | Integrin alphaIIb beta3 'outside-in' signalling involves multiple proteins including SRC, SYK, SLP-76 and PLCgamma2. SRC is constitutively associated with the C-terminal tail of integrin beta 3. SYK is recruited to the beta3 tail and subsequently activated by SRC. |
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| (summation) | [Reaction:429415] SYK binds to integrin alphaIIb beta3 [Homo sapiens] |
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