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Details on Person ALOX5 is phosphorylated by MAPKAP2

Class:IdReaction:429016
_displayNameALOX5 is phosphorylated by MAPKAP2
_doReleaseTRUE
_timestamp2024-08-02 18:54:32
authored[InstanceEdit:429170] Jupe, S, 2009-07-14
catalystActivity[CatalystActivity:429015] protein serine/threonine kinase activity of p-S272,T222,T334-MAPKAPK2 [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:429020] Jupe, S, 2009-07-14
crossReference[DatabaseIdentifier:9857128] RHEA:17990
edited[InstanceEdit:686124] Jupe, S, 2010-05-06
input[Complex:2237880] ALOX5:Ca2+:Fe2+ [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
internalReviewed[InstanceEdit:9917225] D'Eustachio, Peter, 2024-08-01
literatureReference[LiteratureReference:429018] 5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases
[LiteratureReference:429019] Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2)
modified[InstanceEdit:430261] Jupe, S, 2009-08-06
[InstanceEdit:706474] D'Eustachio, P, 2010-05-10
[InstanceEdit:708311] Jupe, S, 2010-05-10
[InstanceEdit:2237881] Jassal, B, 2012-05-08
[InstanceEdit:2569041] D'Eustachio, P, 2012-11-10
[InstanceEdit:9613058] D'Eustachio, Peter, 2018-07-09
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9915828] D'Eustachio, Peter, 2024-07-16
[InstanceEdit:9917368] D'Eustachio, Peter, 2024-08-02
nameALOX5 is phosphorylated by MAPKAP2
ATP + L-seryl-(protein) => ADP + H(+) + O-phospho-L-seryl-(protein)
output[Complex:265277] p-S272-ALOX5:Ca2+:Fe2+ [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:70106] H+ [cytosol]
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2010-06-15
reviewed[InstanceEdit:2569042] Rush, MG, 2012-11-10
[InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105781] R-HSA-429016.4
structureModified[InstanceEdit:9915828] D'Eustachio, Peter, 2024-07-16
summation[Summation:429012] Arachidonate 5-lipoxygenase (ALOX5) catalyzes the first step...
(hasEvent)[Pathway:2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) [Homo sapiens]
(precedingEvent)[Reaction:265296] Arachidonate is oxidised to 5S-HpETE by ALOX5 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9779148] Update Tracker - [Reaction:429016] ALOX5 is phosphorylated by MAPKAP2 - v66:[addInput, addOutput]
[_UpdateTracker:9788694] Update Tracker - [Reaction:429016] ALOX5 is phosphorylated by MAPKAP2 - v41:[add_removeInput, add_removeOutput]
[_UpdateTracker:9919504] Update Tracker - [Reaction:429016] ALOX5 is phosphorylated by MAPKAP2 - v90:[modifyText, removeOutput]
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