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Details on Person SLC27A1 transports arachidonate across the ER membrane

Class:Id	Reaction:428990
_displayName	SLC27A1 transports arachidonate across the ER membrane
_doRelease	TRUE
_timestamp	2024-08-02 17:21:07
authored	[InstanceEdit:428984] Jupe, S, 2009-07-14
catalystActivity	[CatalystActivity:9915567] icosanoid transmembrane transporter activity of SLC27A1 [endoplasmic reticulum membrane]
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:428989] Jupe, S, 2009-07-14
crossReference	[DatabaseIdentifier:9915558] RHEA:71395
edited	[InstanceEdit:428989] Jupe, S, 2009-07-14
inferredFrom	[Reaction:9915559] Slc27a1 transports arachidonate across the ER membrane [Mus musculus]
input	[SimpleEntity:140356] AA [endoplasmic reticulum lumen]
internalReviewed	[InstanceEdit:9917225] D'Eustachio, Peter, 2024-08-01
literatureReference	[LiteratureReference:9915550] Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells [LiteratureReference:428991] How is the level of free arachidonic acid controlled in mammalian cells? [LiteratureReference:9915538] Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein
modified	[InstanceEdit:2569041] D'Eustachio, P, 2012-11-10 [InstanceEdit:2581441] D'Eustachio, P, 2012-11-13 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9037750] Jassal, Bijay, 2018-02-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9915565] D'Eustachio, Peter, 2024-07-11 [InstanceEdit:9917361] D'Eustachio, Peter, 2024-08-02
name	SLC27A1 transports arachidonate across the ER membrane (5Z,8Z,11Z,14Z)-eicosatetraenoate(out) = (5Z,8Z,11Z,14Z)-eicosatetraenoate(in)
output	[SimpleEntity:29768] AA [cytosol]
precedingEvent	[Reaction:111883] PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine [Homo sapiens] [Reaction:111881] Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-12-04
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10 [InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200423] R-HSA-428990.5
structureModified	[InstanceEdit:9915565] D'Eustachio, Peter, 2024-07-11
summation	[Summation:428987] Cytosolic arachidonate (AA) released by phospholipases is tr...
(hasEvent)	[Pathway:2142753] Arachidonate metabolism [Homo sapiens]
(precedingEvent)	[Reaction:265296] Arachidonate is oxidised to 5S-HpETE by ALOX5 [Homo sapiens] [Reaction:429005] Lysophospholipid acyltransferase 5 converts lysophosphatidylcholine to phosphatidylcholine [Homo sapiens] [Reaction:2161794] Arachidonate is converted to HXA3/B3 by ALOX12 [Homo sapiens] [Reaction:2161890] Arachidonate is epoxidated to 5,6-EET by CYP(4) [Homo sapiens] [Reaction:2161899] Arachidonate is epoxidated to 8,9-EET by CYP(5) [Homo sapiens] [Reaction:2161948] Arachidonate is converted to 12-oxoETE by ALOX12 [Homo sapiens] [Reaction:2161950] Arachidonate is oxidised to 12R-HpETE by ALOX12B [Homo sapiens] [Reaction:2161951] Arachidonate is oxidised to 15R-HETE by Acetyl-PTGS2 [Homo sapiens] [Reaction:2161964] Arachidonate is oxidised to 12S-HpETE by ALOX12/15 [Homo sapiens] [Reaction:2162002] Arachidonate is oxidised to 15S-HpETE by ALOX15/15B [Homo sapiens] List all 12 refering instances
(updatedInstance)	[_UpdateTracker:9919466] Update Tracker - [Reaction:428990] SLC27A1 transports arachidonate across the ER membrane - v90:[modifyText, removeCatalystActivity, removeLiteratureReference]
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