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Details on Person MAPK p38 alpha activates cPLA2 by phosphorylation of two se...

Class:IdSummation:428963
_displayName MAPK p38 alpha activates cPLA2 by phosphorylation of two se...
_timestamp2010-06-01 14:53:07
created[InstanceEdit:428965] Jupe, S, 2009-07-13
literatureReference[LiteratureReference:428959] p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2
[LiteratureReference:378463] Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells
[LiteratureReference:111951] cPLA2 is phosphorylated and activated by MAP kinase
[LiteratureReference:866444] Differential activation of cytosolic phospholipase A2 (cPLA2) by thrombin and thrombin receptor agonist peptide in human platelets. Evidence for activation of cPLA2 independent of the mitogen-activated protein kinases ERK1/2
[LiteratureReference:866434] Cytosolic phospholipase A2 is phosphorylated in collagen- and thrombin-stimulated human platelets independent of protein kinase C and mitogen-activated protein kinase
[LiteratureReference:866435] Inhibition of mitogen-activated protein kinase kinase does not impair primary activation of human platelets
modified[InstanceEdit:866439] Jupe, S, 2010-06-01
text MAPK p38 alpha activates cPLA2 by phosphorylation of two serine residues.
cPLA2 can be phosphorylated and activated by ERK2 (Lin et al. 1993), and were believed to be responsible for the phosphorylation of cPLA2. However, phosphorylation of cPLA2 occurred in the absence of ERK activation in human platelets stimulated with the thrombin receptor agonist peptide SFLLRN (Kramer et al. 1995), and cPLA2 phosphorylation induced by thrombin or collagen was unaffected by PKC inhibitors that prevent ERK activation (Börsch-Haubold et al. 1995). In addition, a specific inhibitor of ERKs did not block thrombin-induced cPLA2 phosphorylation (Börsch-Haubold et al. 1996).
(summation)[Reaction:428961] Phosphorylation of cPLA2 by MAPK p38 alpha [Homo sapiens]
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