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Details on Person ADP activates human platelets and induces endothelial cell m...

Class:Id	Summation:428942
_displayName	ADP activates human platelets and induces endothelial cell m...
_timestamp	2012-04-23 13:18:19
created	[InstanceEdit:428943] Jupe, S, 2009-07-13
literatureReference	[LiteratureReference:428945] ADP stimulates human endothelial cell migration via P2Y1 nucleotide receptor-mediated mitogen-activated protein kinase pathways [LiteratureReference:428944] The P2Y1 receptor mediates ADP-induced p38 kinase-activating factor generation in human platelets [LiteratureReference:2206195] The lipid raft proteins flotillins/reggies interact with Galphaq and are involved in Gq-mediated p38 mitogen-activated protein kinase activation through tyrosine kinase
modified	[InstanceEdit:2206197] Jupe, S, 2012-04-23
text	ADP activates human platelets and induces endothelial cell migration. These effects are partly mediated by the P2Y1 purinocetor, inducing p38 MAP kinase activation via an uncharacterised factor. Possible mechanisms include flotillin-mediated stimulation of SRC family kinases in lipid rafts (Sugawara et al. 2007).
(summation)	[BlackBoxEvent:428941] P2Y purinoceptor 1 activates MAP kinase p38 alpha [Homo sapiens]
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