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Details on Person Dissociation of the TP:Gq complex

Class:Id	Reaction:428752
_displayName	Dissociation of the TP:Gq complex
_doRelease	TRUE
_timestamp	2010-12-02 14:35:38
authored	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:428751] Jupe, S, 2009-07-09
edited	[InstanceEdit:445674] Jupe, S, 2009-11-03
input	[Complex:428904] TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:427945] Dissociation of heterotrimeric g proteins in cells
modified	[InstanceEdit:428919] Jupe, S, 2009-07-13 [InstanceEdit:435393] Jupe, S, 2009-09-09 [InstanceEdit:445674] Jupe, S, 2009-11-03 [InstanceEdit:446291] Jupe, S, 2009-11-12 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dissociation of the TP:Gq complex
output	[SimpleEntity:391932] TXA2 [extracellular region] [EntityWithAccessionedSequence:391837] TBXA2R [plasma membrane] [Homo sapiens] [Complex:167434] G-protein beta-gamma complex [plasma membrane] [Homo sapiens] [Complex:114534] G-protein alpha (q/11): GTP [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:428750] Gq activation by TP receptor [Homo sapiens] [Reaction:428749] Activated TP receptor binds G-proten Gq [Homo sapiens]
releaseDate	2009-12-15
reviewed	[InstanceEdit:445668] Poole, AW, 2009-11-02 [InstanceEdit:445653] Jones, ML, 2009-11-02 [InstanceEdit:445649] Harper, MT, 2009-11-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104731] R-HSA-428752.2
summation	[Summation:392198] The classical view of G-protein signalling is that the G-pro...
(hasEvent)	[Pathway:428930] Thromboxane signalling through TP receptor [Homo sapiens]
(precedingEvent)	[Reaction:398188] PLC beta is activated by G alpha (q) [Homo sapiens] [Reaction:400586] G alpha (q) binds to Trio family RhoGEFs [Homo sapiens] [Reaction:416358] G alpha (q) inhibits PI3K alpha [Homo sapiens] [Reaction:416510] GRK5 sequesters activated Gq [Homo sapiens] [Reaction:416516] GRK2 sequesters activated Gq [Homo sapiens] [Reaction:418582] G alpha (q) auto-inactivates by hydrolysing GTP to GDP [Homo sapiens] [Reaction:8964156] GNB1:GNG2 binds ARHGEF18 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790505] Update Tracker - [Reaction:428752] Dissociation of the TP:Gq complex - v33:[modifyText]
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