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Details on Person PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate

Class:IdReaction:428696
_displayNamePLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate
_doReleaseTRUE
_timestamp2023-10-24 08:03:29
authored[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
catalystActivity[CatalystActivity:428693] sphingosine-1-phosphate phosphatase activity of PLPP1,2,3 [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:428672] D'Eustachio, P, 2009-07-06
edited[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
input[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:428203] C18-S1P [cytosol]
literatureReference[LiteratureReference:200173] Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform.
[LiteratureReference:9844350] Lipid phosphate phosphatases and their roles in mammalian physiology and pathology
[LiteratureReference:9844345] Lipid Phosphate Phosphatases and Cancer
modified[InstanceEdit:428698] D'Eustachio, P, 2009-07-06
[InstanceEdit:433040] D'Eustachio, P, 2009-08-20
[InstanceEdit:446904] D'Eustachio, P, 2009-11-18
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:1660664] Jassal, B, 2011-10-14
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9841787] Stephan, Ralf, 2023-08-12
[InstanceEdit:9844337] Stephan, Ralf, 2023-09-15
[InstanceEdit:9851294] Stephan, Ralf, 2023-10-20
[InstanceEdit:9851345] Stephan, Ralf, 2023-10-24
namePLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate
sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]
output[SimpleEntity:29372] Pi [cytosol]
[SimpleEntity:1132148] sphingosine [cytoplasm]
precedingEvent
releaseDate2009-09-30
reviewed[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18
[InstanceEdit:433039] Jassal, B, 2009-08-20
[InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105295] R-HSA-428696.4
summation[Summation:428692] Phospholipid phosphatases 1 (PLPP1, PPAP2A, LPP1), 2 (PLPP2,...
(hasEvent)[Pathway:9845614] Sphingolipid catabolism [Homo sapiens]
(precedingEvent)[Reaction:428273] SPHK1 phosphorylates sphingoid [Homo sapiens]
[Reaction:9695949] SPHK2 phosphorylates sphingoid [Homo sapiens]
(updatedInstance)[_UpdateTracker:9853219] Update Tracker - [Reaction:428696] PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate - v87:[addLiteratureReference, add_removeOutput, modifyText]
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