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Details on Person PLPP1 dephosphorylates extracellular sphingosine-1-phosphate

Class:Id	Reaction:428690
_displayName	PLPP1 dephosphorylates extracellular sphingosine-1-phosphate
_doRelease	TRUE
_timestamp	2023-10-24 08:03:20
authored	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
catalystActivity	[CatalystActivity:428666] sphingosine-1-phosphate phosphatase activity of PLPP1 [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:428672] D'Eustachio, P, 2009-07-06
edited	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
input	[SimpleEntity:109276] H2O [extracellular region] [SimpleEntity:419305] C18-S1P [extracellular region]
literatureReference	[LiteratureReference:200173] Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform. [LiteratureReference:9844338] Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1 [LiteratureReference:9844350] Lipid phosphate phosphatases and their roles in mammalian physiology and pathology
modified	[InstanceEdit:428698] D'Eustachio, P, 2009-07-06 [InstanceEdit:433040] D'Eustachio, P, 2009-08-20 [InstanceEdit:446904] D'Eustachio, P, 2009-11-18 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9841787] Stephan, Ralf, 2023-08-12 [InstanceEdit:9843740] Stephan, Ralf, 2023-09-10 [InstanceEdit:9844337] Stephan, Ralf, 2023-09-15 [InstanceEdit:9851294] Stephan, Ralf, 2023-10-20 [InstanceEdit:9851345] Stephan, Ralf, 2023-10-24
name	PLPP1 dephosphorylates extracellular sphingosine-1-phosphate sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]
output	[SimpleEntity:109277] Pi [extracellular region] [SimpleEntity:1132148] sphingosine [cytoplasm]
precedingEvent	[Reaction:9695890] SPNS2,MFSD2B transport S1P from cytosol to extracellular region [Homo sapiens] [Reaction:428273] SPHK1 phosphorylates sphingoid [Homo sapiens] [Reaction:9695949] SPHK2 phosphorylates sphingoid [Homo sapiens] [Reaction:9843721] ABCC1,ABCG2 transport C18-S1P to extracellular region [Homo sapiens] [Reaction:428273] SPHK1 phosphorylates sphingoid [Homo sapiens] [Reaction:9695949] SPHK2 phosphorylates sphingoid [Homo sapiens]
releaseDate	2009-09-30
reviewed	[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18 [InstanceEdit:433039] Jassal, B, 2009-08-20 [InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105450] R-HSA-428690.4
summation	[Summation:428695] Phospholipid phosphatase 2 (PLPP2, PPAP2A, LPP3) enzyme asso...
(hasEvent)	[Pathway:9845614] Sphingolipid catabolism [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9853236] Update Tracker - [Reaction:428690] PLPP1 dephosphorylates extracellular sphingosine-1-phosphate - v87:[addLiteratureReference, add_removeOutput, modifyText]
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