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| Class:Id | Summation:428596 |
|---|---|
| _displayName | Four SLC17 genes are thought to encode type I Na+-dependent ... |
| _timestamp | 2009-08-24 12:03:33 |
| created | [InstanceEdit:428570] Jassal, Bijay, 2009-07-06 |
| modified | [InstanceEdit:433656] Jassal, B, 2009-08-24 |
| text | Four SLC17 genes are thought to encode type I Na+-dependent phosphate co-transporters in humans. SLC17A1 (NPT1) encodes Na+-dependent phosphate co-transporter 1 (Na/Pi-4). It is abundant in human kidney cortex, liver and brain and is important for the resorption of phosphate by the kidney. It does this by actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane (Chong SS et al, 1993). Three close relatives of NPT1 have been identified through genomic analysis and designated NPT3 (SLC17A2), NPT4 (SLC17A3) and a putative small intestine sodium-dependent phosphate co-transporter (SLC17A4). None of these three proteins have been functionally characterized yet. |
| (summation) | [Reaction:428609] Type I Na+-coupled phosphate co-transport [Homo sapiens] |
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