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Details on Person ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing

Class:Id	BlackBoxEvent:428510
_displayName	ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing
_doRelease	TRUE
_timestamp	2017-11-17 16:24:17
authored	[InstanceEdit:376175] Garapati, P V, 2008-09-05 06:02:05
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:428526] Garapati, P V, 2009-07-06
edited	[InstanceEdit:376175] Garapati, P V, 2008-09-05 06:02:05 [InstanceEdit:9009839] Orlic-Milacic, Marija, 2017-06-23
input	[EntityWithAccessionedSequence:426410] ROBO3.1 [plasma membrane] [Homo sapiens] [CandidateSet:9014787] ROBO2,(ROBO1) [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:9010997] Robo3.1A suppresses slit-mediated repulsion by triggering degradation of Robo2
modified	[InstanceEdit:428881] Garapati, P V, 2009-07-10 [InstanceEdit:434971] Garapati, P V, 2009-09-04 [InstanceEdit:9009841] Orlic-Milacic, Marija, 2017-06-23 [InstanceEdit:9014790] Orlic-Milacic, Marija, 2017-08-03 [InstanceEdit:9014895] Orlic-Milacic, Marija, 2017-08-04 [InstanceEdit:9015666] Orlic-Milacic, Marija, 2017-08-10 [InstanceEdit:9029384] Orlic-Milacic, Marija, 2017-11-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing
output	[Complex:428496] ROBO2,(ROBO1):ROBO3.1 [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9011083] ROBO1 gene expression is inhibited by LHX2 [Homo sapiens] [Reaction:9011074] LHX2 binds to ROBO1 gene locus [Homo sapiens] [BlackBoxEvent:9010523] ROBO2 gene transcription is stimulated by HOXA2 and inhibited by LHX2 [Homo sapiens] [Reaction:9010503] HOXA2 binds ROBO2 gene promoter [Homo sapiens] [Reaction:9011077] LHX2 binds to ROBO2 gene locus [Homo sapiens] [BlackBoxEvent:9011347] ROBO3.1 mRNA translation is positively regulated by MSI1 [Homo sapiens] [BlackBoxEvent:9011143] ROBO3.1 expression is stimulated by LHX2,(LHX9) [Homo sapiens]
releaseDate	2009-09-30
reviewed	[InstanceEdit:434966] Kidd, T, 2009-08-18 [InstanceEdit:9014887] Jaworski, Alexander, 2017-07-31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105661] R-HSA-428510.4
summation	[Summation:428432] ROBO3 antagonizes ROBO1/ROBO2 function to prevent their resp...
(hasEvent)	[Pathway:428542] Regulation of commissural axon pathfinding by SLIT and ROBO [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780527] Update Tracker - [BlackBoxEvent:428510] ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing - v62:[addLiteratureReference, add_removeInput, modifyText]
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