Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person SRGAP bound to ROBO's cytoplasmic tail increases the intrins...

Class:IdSummation:428409
_displayNameSRGAP bound to ROBO's cytoplasmic tail increases the intrins...
_timestamp2017-06-26 14:51:16
created[InstanceEdit:428425] Garapati, P V, 2009-07-06
literatureReference[LiteratureReference:428412] Structural basis of Robo proline-rich motif recognition by the srGAP1 Src homology 3 domain in the Slit-Robo signaling pathway
[LiteratureReference:375968] Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway
modified[InstanceEdit:428947] Garapati, P V, 2009-07-13
[InstanceEdit:429545] Garapati, P V, 2009-07-16
[InstanceEdit:9010156] Orlic-Milacic, Marija, 2017-06-26
textSRGAP bound to ROBO's cytoplasmic tail increases the intrinsic GTPase activity of CDC42, converting the GTP-bound form of CDC42 into its GDP-bound form, therefore inactivating CDC42. Inactivation of CDC42 leads to a reduction in the activation of the Neuronal Wiskott-Aldrich Syndrome protein (NWASP), thus decreasing the level of the active Arp2/3 complex. Because active Arp2/3 promotes actin polymerization, the reduction of active CDC42 eventually decreases actin polymerization. SLIT regulates SRGAP interaction with ROBO1 and CDC42, increasing SRGAP binding to CDC42 (Wong et al. 2001, Li et al. 2006).
(summation)[Reaction:428533] Inactivation of CDC42 [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by SRGAP bound to ROBO's cytoplasmic tail increases the intrins... (428409)
Follow Reactome