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Details on Person Vilse/CrossGAP (CrGAP), a conserved Rac-specific GAP in Dros...
| Class:Id | Summation:428408 |
|---|---|
| _displayName | Vilse/CrossGAP (CrGAP), a conserved Rac-specific GAP in Dros... |
| _timestamp | 2017-06-30 15:44:39 |
| created | [InstanceEdit:428425] Garapati, P V, 2009-07-06 |
| literatureReference | [LiteratureReference:428411] Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons [LiteratureReference:428435] Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion |
| modified | [InstanceEdit:428947] Garapati, P V, 2009-07-13 [InstanceEdit:9010156] Orlic-Milacic, Marija, 2017-06-26 [InstanceEdit:9011442] Orlic-Milacic, Marija, 2017-06-30 |
| text | Vilse/CrossGAP (CrGAP), a conserved Rac-specific GAP in Drosophila, is involved in Robo mediated repulsion. CrGAP directly interacts with Robo, both biochemically and genetically. The biochemical interaction is mediated by the WW domains in CrGAP and the CC2 motif of Robo. The human homologue of Vilse/CrGAP, ARHGAP39 (also known as KIAA1688), was identified. ARHGAP39 shares 54.4% sequence identity with Drosophila CrGAP and is referred to as human Vilse/CrGAP protein (Lundstrom et al. 2004, Hu et al. 2005). |
| (summation) | [Reaction:428536] ARHGAP39 (Vilse) binds ROBO1:SLIT2 [Homo sapiens] |
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No pathways have been reviewed or authored by Vilse/CrossGAP (CrGAP), a conserved Rac-specific GAP in Dros... (428408)
