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Details on Person ACER1 (alkaline ceramidase 1) catalyzes the reversible hydro...
| Class:Id | Summation:428263 |
|---|---|
| _displayName | ACER1 (alkaline ceramidase 1) catalyzes the reversible hydro... |
| _timestamp | 2023-09-13 08:08:12 |
| created | [InstanceEdit:428277] D'Eustachio, P, 2009-07-03 |
| modified | [InstanceEdit:428280] D'Eustachio, P, 2009-07-03 [InstanceEdit:434869] D'Eustachio, P, 2009-09-03 [InstanceEdit:1606607] Jassal, B, 2011-09-23 [InstanceEdit:9844143] Stephan, Ralf, 2023-09-13 |
| text | ACER1 (alkaline ceramidase 1) catalyzes the reversible hydrolysis of ceramide to yield a free fatty acid and sphingosine (Sun et al. 2008). ACER1 hydrolyses C20:0-C24:0 ceramides, localizes to the endoplasmic reticulum membrane, and is mainly expressed in skin tissue (Casasampere et al., 2015). ACER1 is believed to be a key regulator of keratinocyte differentiation and has a fundamental role in skin barrier formation (Liakath-Ali et al., 2016; reviewed by Mao & Obeid, 2008; Parveen et al., 2019; Duarte et al., 2020). |
| (summation) | [Reaction:428231] ACER1 hydrolyzes ceramide (endoplasmic reticulum) [Homo sapiens] |
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No pathways have been reviewed or authored by ACER1 (alkaline ceramidase 1) catalyzes the reversible hydro... (428263)
