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Details on Person DEGS2 oxygenates dihydroceramide

Class:IdReaction:428260
_displayNameDEGS2 oxygenates dihydroceramide
_doReleaseTRUE
_timestamp2023-10-24 07:53:43
authored[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
catalystActivity[CatalystActivity:428238] sphingolipid C4-monooxygenase activity of DEGS2 [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:428277] D'Eustachio, P, 2009-07-03
edited[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
input[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:29368] O2 [cytosol]
[SimpleEntity:428126] DHCE [endoplasmic reticulum membrane]
[Complex:9842697] CYB5B:Fe2+ [endoplasmic reticulum membrane] [Homo sapiens]
literatureReference[LiteratureReference:428255] Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation
[LiteratureReference:9843175] Bifunctional DEGS2 has higher hydroxylase activity toward substrates with very-long-chain fatty acids in the production of phytosphingosine ceramides
modified[InstanceEdit:428280] D'Eustachio, P, 2009-07-03
[InstanceEdit:433040] D'Eustachio, P, 2009-08-20
[InstanceEdit:446904] D'Eustachio, P, 2009-11-18
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:1660664] Jassal, B, 2011-10-14
[InstanceEdit:9032935] D'Eustachio, Peter, 2017-12-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9841785] Stephan, Ralf, 2023-08-12
[InstanceEdit:9843179] Stephan, Ralf, 2023-09-01
[InstanceEdit:9851294] Stephan, Ralf, 2023-10-20
[InstanceEdit:9851343] Stephan, Ralf, 2023-10-24
nameDEGS2 oxygenates dihydroceramide
dihydroceramide + Fe2+ + H+ + O2 => phytoceramide + Fe3+ + H2O
output[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:9025544] phytoceramide [endoplasmic reticulum membrane]
[Complex:9842694] CYB5B:Fe3+ [endoplasmic reticulum membrane] [Homo sapiens]
precedingEvent
releaseDate2009-09-30
reviewed[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18
[InstanceEdit:433039] Jassal, B, 2009-08-20
[InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105513] R-HSA-428260.5
summation[Summation:428247] DEGS2 (sphingolipid C4-hydroxylase 2 / “degenerative spermat...
(hasEvent)[Pathway:1660661] Sphingolipid de novo biosynthesis [Homo sapiens]
(inferredFrom)[Reaction:433593] dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O [Gallus gallus]
(precedingEvent)[Reaction:428262] ACER3 hydrolyzes phytoceramide [Homo sapiens]
(updatedInstance)[_UpdateTracker:9780042] Update Tracker - [Reaction:428260] dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O - v64:[add_removeOutput]
[_UpdateTracker:9782341] Update Tracker - [Reaction:428260] dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O - v59:[modifyText]
[_UpdateTracker:9783127] Update Tracker - [Reaction:428260] dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O - v57:[modifyText]
[_UpdateTracker:9784829] Update Tracker - [Reaction:428260] dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O - v53:[modifyText]
[_UpdateTracker:9789709] Update Tracker - [Reaction:428260] dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O - v37:[modifyText]
[_UpdateTracker:9853223] Update Tracker - [Reaction:428260] DEGS2 oxygenates dihydroceramide - v87:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
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