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Details on Person DEGS1 dehydrogenates dihydroceramide

Class:IdReaction:428259
_displayNameDEGS1 dehydrogenates dihydroceramide
_doReleaseTRUE
_timestamp2023-10-24 07:53:34
authored[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
catalystActivity[CatalystActivity:428230] sphingolipid delta-4 desaturase activity of DEGS1 [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:428277] D'Eustachio, P, 2009-07-03
edited[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
input[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:29368] O2 [cytosol]
[SimpleEntity:428126] DHCE [endoplasmic reticulum membrane]
[Complex:9842697] CYB5B:Fe2+ [endoplasmic reticulum membrane] [Homo sapiens]
[Complex:9842697] CYB5B:Fe2+ [endoplasmic reticulum membrane] [Homo sapiens]
literatureReference[LiteratureReference:428272] Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide
[LiteratureReference:428213] Identification and characterization of a sphingolipid delta 4-desaturase family
[LiteratureReference:428242] The product of the MLD gene is a member of the membrane fatty acid desaturase family: overexpression of MLD inhibits EGF receptor biosynthesis
[LiteratureReference:9843163] Dihydroceramide desaturase and dihydrosphingolipids: debutant players in the sphingolipid arena
[LiteratureReference:9843150] Conversion of dihydroceramide into ceramide: involvement of a desaturase
[LiteratureReference:9843162] DEGS1 -related leukodystrophy: a clinical report and review of literature
[LiteratureReference:9843158] The pathophysiological role of dihydroceramide desaturase in the nervous system
modified[InstanceEdit:428280] D'Eustachio, P, 2009-07-03
[InstanceEdit:433040] D'Eustachio, P, 2009-08-20
[InstanceEdit:446904] D'Eustachio, P, 2009-11-18
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:1660664] Jassal, B, 2011-10-14
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9841785] Stephan, Ralf, 2023-08-12
[InstanceEdit:9841793] Stephan, Ralf, 2023-08-12
[InstanceEdit:9842402] Stephan, Ralf, 2023-08-27
[InstanceEdit:9842696] Stephan, Ralf, 2023-08-28
[InstanceEdit:9843169] Stephan, Ralf, 2023-09-01
[InstanceEdit:9851294] Stephan, Ralf, 2023-10-20
[InstanceEdit:9851343] Stephan, Ralf, 2023-10-24
nameDEGS1 dehydrogenates dihydroceramide
dihydroceramide + 2Fe(2+) + 2H+ + O2 => (4E)-ceramide + 2Fe(3+) + 2H2O
negativePrecedingEvent[NegativePrecedingEvent:9841788] Abundant Molecules: ALDH3A2-1 oxidises HD2NAL to PALM
[NegativePrecedingEvent:9841789] Abundant Molecules: ALDH3B1 oxidises HXAL to PALM
[NegativePrecedingEvent:9841792] Abundant Molecules: ALDH3B2 oxidises HXAL to PALM
output[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:9842380] (4E)-CERA [endoplasmic reticulum membrane]
[Complex:9842694] CYB5B:Fe3+ [endoplasmic reticulum membrane] [Homo sapiens]
[Complex:9842694] CYB5B:Fe3+ [endoplasmic reticulum membrane] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
releaseDate2009-09-30
reviewed[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18
[InstanceEdit:433039] Jassal, B, 2009-08-20
[InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105918] R-HSA-428259.4
structureModified[InstanceEdit:9842696] Stephan, Ralf, 2023-08-28
summation[Summation:428244] DEGS1 (DES1, sphingolipid delta(4)-desaturase 1 / “degenerat...
(hasEvent)[Pathway:1660661] Sphingolipid de novo biosynthesis [Homo sapiens]
(inferredFrom)[Reaction:433599] dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O [Gallus gallus]
(precedingEvent)[NegativePrecedingEvent:9841790] Abundant Molecules: DEGS1 dehydrogenates dihydroceramide
[NegativePrecedingEvent:9841791] Abundant Molecules: DEGS1 dehydrogenates dihydroceramide
[NegativePrecedingEvent:9841794] Abundant Molecules: DEGS1 dehydrogenates dihydroceramide
[Reaction:428231] ACER1 hydrolyzes ceramide (endoplasmic reticulum) [Homo sapiens]
[Reaction:8959462] SAMD8 transfers phosphatidyl from PE onto C16DH CER [Homo sapiens]
(updatedInstance)[_UpdateTracker:9782131] Update Tracker - [Reaction:428259] dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O - v59:[modifyText]
[_UpdateTracker:9783337] Update Tracker - [Reaction:428259] dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O - v57:[modifyText]
[_UpdateTracker:9784585] Update Tracker - [Reaction:428259] dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O - v53:[modifyText]
[_UpdateTracker:9789589] Update Tracker - [Reaction:428259] dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O - v37:[modifyText]
[_UpdateTracker:9853256] Update Tracker - [Reaction:428259] DEGS1 dehydrogenates dihydroceramide - v87:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
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