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Details on Person ACER1 hydrolyzes ceramide (endoplasmic reticulum)

Class:IdReaction:428231
_displayNameACER1 hydrolyzes ceramide (endoplasmic reticulum)
_doReleaseTRUE
_timestamp2023-10-24 08:02:20
authored[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
catalystActivity[CatalystActivity:428216] N-acylsphingosine amidohydrolase activity of ACER1 [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:428277] D'Eustachio, P, 2009-07-03
edited[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
input[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:428256] CERA [endoplasmic reticulum membrane]
literatureReference[LiteratureReference:428202] Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes
[LiteratureReference:9843845] Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate
[LiteratureReference:9843863] Elusive Roles of the Different Ceramidases in Human Health, Pathophysiology, and Tissue Regeneration
[LiteratureReference:9843856] Role of Ceramidases in Sphingolipid Metabolism and Human Diseases
[LiteratureReference:9844129] Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols
[LiteratureReference:9844133] Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole-body energy expenditure
modified[InstanceEdit:428280] D'Eustachio, P, 2009-07-03
[InstanceEdit:433040] D'Eustachio, P, 2009-08-20
[InstanceEdit:434869] D'Eustachio, P, 2009-09-03
[InstanceEdit:446904] D'Eustachio, P, 2009-11-18
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:1660664] Jassal, B, 2011-10-14
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9841787] Stephan, Ralf, 2023-08-12
[InstanceEdit:9843844] Stephan, Ralf, 2023-09-12
[InstanceEdit:9844143] Stephan, Ralf, 2023-09-13
[InstanceEdit:9844176] Stephan, Ralf, 2023-09-14
[InstanceEdit:9851294] Stephan, Ralf, 2023-10-20
[InstanceEdit:9851345] Stephan, Ralf, 2023-10-24
nameACER1 hydrolyzes ceramide (endoplasmic reticulum)
ceramide + H2O <=> fatty acid + sphingosine (endoplasmic reticulum)
output[SimpleEntity:1861754] RCOO- [cytosol]
[SimpleEntity:428682] SPG [cytosol]
precedingEvent
releaseDate2009-09-30
reviewed[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18
[InstanceEdit:433039] Jassal, B, 2009-08-20
[InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104465] R-HSA-428231.4
summation[Summation:428263] ACER1 (alkaline ceramidase 1) catalyzes the reversible hydro...
(hasEvent)[Pathway:9845614] Sphingolipid catabolism [Homo sapiens]
(inferredFrom)[Reaction:433608] ceramide + H2O => stearate + sphingosine [endoplasmic reticulum] [Gallus gallus]
(precedingEvent)[Reaction:428273] SPHK1 phosphorylates sphingoid [Homo sapiens]
[Reaction:9695949] SPHK2 phosphorylates sphingoid [Homo sapiens]
(updatedInstance)[_UpdateTracker:9853178] Update Tracker - [Reaction:428231] ACER1 hydrolyzes ceramide (endoplasmic reticulum) - v87:[addLiteratureReference, add_removeOutput, modifyText]
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