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Details on Person SPHK1,SPHK2 phosphorylate sphingoid

Class:Id	Reaction:428214
_displayName	SPHK1,SPHK2 phosphorylate sphingoid
_doRelease	FALSE
_timestamp	2024-11-15 06:32:08
authored	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
catalystActivity	[CatalystActivity:428215] sphingosine kinase activity of SPHK1,SPHK2 [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:428277] D'Eustachio, P, 2009-07-03
edited	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:5279323] sphingoid base [cytoplasm]
literatureReference	[LiteratureReference:428217] Functional characterization of human sphingosine kinase-1 [LiteratureReference:428279] Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes [LiteratureReference:428274] Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform
modified	[InstanceEdit:428280] D'Eustachio, P, 2009-07-03 [InstanceEdit:428672] D'Eustachio, P, 2009-07-06 [InstanceEdit:433040] D'Eustachio, P, 2009-08-20 [InstanceEdit:446904] D'Eustachio, P, 2009-11-18 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1660664] Jassal, B, 2011-10-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9841785] Stephan, Ralf, 2023-08-12 [InstanceEdit:9842411] Stephan, Ralf, 2023-08-27 [InstanceEdit:9843248] Stephan, Ralf, 2023-09-06 [InstanceEdit:9843384] Stephan, Ralf, 2023-09-08 [InstanceEdit:9928387] Matthews, Lisa, 2024-11-15
name	SPHK1,SPHK2 phosphorylate sphingoid sphingoid base +ATP => sphingoid 1-phosphate + ADP + H+
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:5279322] S1P [cytoplasm] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:428664] SGPP1,2 dephosphorylate sphingoid-1-phosphates [Homo sapiens] [Reaction:428273] SPHK1 phosphorylates sphingoid [Homo sapiens] [Reaction:9695949] SPHK2 phosphorylates sphingoid [Homo sapiens] [Reaction:428123] KDSR reduces 3-ketosphingoid [Homo sapiens] [Reaction:428127] SPTLC complexes transfer acyl-CoA onto serine [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2009-09-30
reviewed	[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18 [InstanceEdit:433039] Jassal, B, 2009-08-20 [InstanceEdit:9928386] Matthews, Lisa, 2024-11-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105299] R-HSA-428214.3
structureModified	[InstanceEdit:9843248] Stephan, Ralf, 2023-09-06
summation	[Summation:428235] SPHK1 and 2 (sphingosine kinases 1 and 2) each catalyze the ...
(updatedInstance)	[_UpdateTracker:9776677] Update Tracker - [Reaction:428214] sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP - v74:[modifyText]
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No pathways have been reviewed or authored by SPHK1,SPHK2 phosphorylate sphingoid (428214)