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Details on Person ACER2 hydrolyzes ceramide (Golgi)

Class:IdReaction:428205
_displayNameACER2 hydrolyzes ceramide (Golgi)
_doReleaseTRUE
_timestamp2025-06-16 19:32:34
authored[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
catalystActivity[CatalystActivity:428257] N-acylsphingosine amidohydrolase activity of ACER2 [Golgi membrane]
compartment[Compartment:20699] Golgi membrane
[Compartment:70101] cytosol
created[InstanceEdit:428277] D'Eustachio, P, 2009-07-03
edited[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
input[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:428270] CERA [Golgi membrane]
literatureReference[LiteratureReference:428268] Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P
[LiteratureReference:9843845] Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate
[LiteratureReference:9843863] Elusive Roles of the Different Ceramidases in Human Health, Pathophysiology, and Tissue Regeneration
[LiteratureReference:9843856] Role of Ceramidases in Sphingolipid Metabolism and Human Diseases
[LiteratureReference:9843875] Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2)
[LiteratureReference:9843851] Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2
[LiteratureReference:9844129] Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols
modified[InstanceEdit:428280] D'Eustachio, P, 2009-07-03
[InstanceEdit:429702] D'Eustachio, P, 2009-07-18
[InstanceEdit:433040] D'Eustachio, P, 2009-08-20
[InstanceEdit:446904] D'Eustachio, P, 2009-11-18
[InstanceEdit:1660664] Jassal, B, 2011-10-14
[InstanceEdit:1864087] Jassal, B, 2011-10-31
[InstanceEdit:8934422] Jassal, Bijay, 2016-08-09
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9841787] Stephan, Ralf, 2023-08-12
[InstanceEdit:9843844] Stephan, Ralf, 2023-09-12
[InstanceEdit:9844143] Stephan, Ralf, 2023-09-13
[InstanceEdit:9844176] Stephan, Ralf, 2023-09-14
[InstanceEdit:9851294] Stephan, Ralf, 2023-10-20
[InstanceEdit:9851345] Stephan, Ralf, 2023-10-24
[InstanceEdit:9956913] D'Eustachio, Peter, 2025-06-16
nameACER2 hydrolyzes ceramide (Golgi)
ceramide + H2O => fatty acid + sphingosine (Golgi)
output[SimpleEntity:1861754] RCOO- [cytosol]
[SimpleEntity:428682] SPG [cytosol]
precedingEvent
releaseDate2009-09-30
reviewed[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18
[InstanceEdit:433039] Jassal, B, 2009-08-20
[InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104437] R-HSA-428205.6
summation[Summation:428243] ACER2 (alkaline ceramidase 2), associated with the membrane ...
(hasEvent)[Pathway:9845614] Sphingolipid catabolism [Homo sapiens]
(updatedInstance)[_UpdateTracker:9782703] Update Tracker - [Reaction:428205] ceramide + H2O => stearate + sphingosine [Golgi] - v58:[add_removeOutput]
[_UpdateTracker:9853270] Update Tracker - [Reaction:428205] ACER2 hydrolyzes ceramide (Golgi) - v87:[addLiteratureReference, add_removeOutput, modifyText]
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