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Details on Person SPTLC complexes transfer acyl-CoA onto serine

Class:Id	Reaction:428127
_displayName	SPTLC complexes transfer acyl-CoA onto serine
_doRelease	TRUE
_timestamp	2023-10-24 07:55:52
authored	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
catalystActivity	[CatalystActivity:428142] serine C-palmitoyltransferase activity of SPTLC complexes [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:428151] D'Eustachio, P, 2009-07-02
edited	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
input	[SimpleEntity:200736] L-Ser [cytosol] [SimpleEntity:1500578] acyl-CoA [cytosol] [SimpleEntity:70106] H+ [cytosol]
literatureReference	[LiteratureReference:428173] Cloning and initial characterization of a new subunit for mammalian serine-palmitoyltransferase [LiteratureReference:428170] Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis [LiteratureReference:428150] Is the mammalian serine palmitoyltransferase a high-molecular-mass complex? [LiteratureReference:428124] Purification of the serine palmitoyltransferase complex responsible for sphingoid base synthesis by using affinity peptide chromatography techniques [LiteratureReference:8865585] Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities [LiteratureReference:8865586] Orm family proteins mediate sphingolipid homeostasis [LiteratureReference:8865579] Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control [LiteratureReference:9842989] Whole picture of human stratum corneum ceramides, including the chain-length diversity of long-chain bases [LiteratureReference:9842992] Structural, mechanistic and regulatory studies of serine palmitoyltransferase [LiteratureReference:9842987] Orm/ORMDL proteins: Gate guardians and master regulators [LiteratureReference:9842988] ORMDL in metabolic health and disease [LiteratureReference:9842996] Mechanistic enzymology of serine palmitoyltransferase [LiteratureReference:9842986] 1-Deoxysphingolipids Encountered Exogenously and Made de Novo: Dangerous Mysteries inside an Enigma
modified	[InstanceEdit:433040] D'Eustachio, P, 2009-08-20 [InstanceEdit:433185] D'Eustachio, P, 2009-08-22 [InstanceEdit:434869] D'Eustachio, P, 2009-09-03 [InstanceEdit:446904] D'Eustachio, P, 2009-11-18 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9695886] Jassal, Bijay, 2020-07-16 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9841797] Stephan, Ralf, 2023-08-14 [InstanceEdit:9841948] Stephan, Ralf, 2023-08-16 [InstanceEdit:9842093] Stephan, Ralf, 2023-08-17 [InstanceEdit:9842402] Stephan, Ralf, 2023-08-27 [InstanceEdit:9842696] Stephan, Ralf, 2023-08-28 [InstanceEdit:9842985] Stephan, Ralf, 2023-08-30 [InstanceEdit:9851294] Stephan, Ralf, 2023-10-20 [InstanceEdit:9851343] Stephan, Ralf, 2023-10-24
name	SPTLC complexes transfer acyl-CoA onto serine acyl-CoA + serine => 3-ketosphingoid + CoASH + CO2
output	[SimpleEntity:76194] CoA-SH [cytosol] [SimpleEntity:113528] CO2 [cytosol] [SimpleEntity:9841798] 3-ketosphingoid [endoplasmic reticulum membrane]
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[NegativeRegulation:8871237] Negative regulation by 'ORMDL1,2,3 [endoplasmic reticulum membrane]'
releaseDate	2009-09-30
reviewed	[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18 [InstanceEdit:433039] Jassal, B, 2009-08-20 [InstanceEdit:9842094] D'Eustachio, Peter, 2023-08-17 [InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105975] R-HSA-428127.6
structureModified	[InstanceEdit:9841797] Stephan, Ralf, 2023-08-14 [InstanceEdit:9841948] Stephan, Ralf, 2023-08-16 [InstanceEdit:9842985] Stephan, Ralf, 2023-08-30
summation	[Summation:428184] SPTLC (serine palmitoyltransferase) enzyme complexes associa...
(hasEvent)	[Pathway:1660661] Sphingolipid de novo biosynthesis [Homo sapiens]
(inferredFrom)	[Reaction:433550] palmitoyl-CoA + serine => 3-dehydrosphinganine + CoASH + CO2 [Gallus gallus]
(precedingEvent)	[Reaction:428123] KDSR reduces 3-ketosphingoid [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776676] Update Tracker - [Reaction:428127] palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 - v74:[add_removeInput] [_UpdateTracker:9783060] Update Tracker - [Reaction:428127] palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 - v57:[addRegulator, modifyText] [_UpdateTracker:9842225] Update Tracker - [Reaction:428127] palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 - v86:[addLiteratureReference, modifyText] [_UpdateTracker:9853218] Update Tracker - [Reaction:428127] SPTLC complexes transfer acyl-CoA onto serine - v87:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText]
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