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Details on Person SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol

Class:Id	Reaction:428015
_displayName	SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol
_doRelease	TRUE
_timestamp	2025-08-14 07:43:07
authored	[InstanceEdit:428008] Jassal, Bijay, 2009-06-30
catalystActivity	[CatalystActivity:428035] high-affinity L-glutamate transmembrane transporter activity of SLC1A1-3,6,7 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:428008] Jassal, Bijay, 2009-06-30
crossReference	[DatabaseIdentifier:9959419] RHEA:70700 [DatabaseIdentifier:9959421] RHEA:70852 [DatabaseIdentifier:9959423] RHEA:71380
edited	[InstanceEdit:428008] Jassal, Bijay, 2009-06-30
input	[SimpleEntity:351626] H+ [extracellular region] [SimpleEntity:74113] Na+ [extracellular region] [SimpleEntity:74113] Na+ [extracellular region] [SimpleEntity:74113] Na+ [extracellular region] [SimpleEntity:29804] K+ [cytosol] [DefinedSet:428027] L-Glu,L-Asp,D-Asp [extracellular region]
literatureReference	[LiteratureReference:428029] Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain [LiteratureReference:428025] Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex [LiteratureReference:427990] Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures [LiteratureReference:428010] An excitatory amino-acid transporter with properties of a ligand-gated chloride channel [LiteratureReference:427979] Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance
modified	[InstanceEdit:428053] Jassal, Bijay, 2009-06-30 [InstanceEdit:433652] Jassal, Bijay, 2009-08-24 [InstanceEdit:5625030] Jassal, Bijay, 2014-10-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9959418] Stephan, Ralf, 2025-06-29 [InstanceEdit:9959422] Stephan, Ralf, 2025-06-29 [InstanceEdit:9963370] Stephan, Ralf, 2025-08-14
name	SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol Glutamate transport
negativePrecedingEvent	[NegativePrecedingEvent:9963409] Futile Cycle: SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate
output	[SimpleEntity:70106] H+ [cytosol] [SimpleEntity:74126] K+ [extracellular region] [SimpleEntity:83910] Na+ [cytosol] [SimpleEntity:83910] Na+ [cytosol] [SimpleEntity:83910] Na+ [cytosol] [DefinedSet:427997] L-Glu,L-Asp,D-Asp [cytosol]
releaseDate	2009-09-30
reviewed	[InstanceEdit:433651] He, L, 2009-08-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105155] R-HSA-428015.3
summation	[Summation:428030] There are two classes of glutamate transporters; the excitat...
(hasEvent)	[Pathway:9958863] SLC-mediated transport of amino acids [Homo sapiens]
(normalReaction)	[FailedReaction:5625015] Defective SLC1A3 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol [Homo sapiens] [FailedReaction:5625029] SLC1A1 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9963229] Abundant Molecules: SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol
(replacementInstances)	[_Deleted:9971768] Deletion of instance: 5250230
(updatedInstance)	[_UpdateTracker:9784382] Update Tracker - [Reaction:428015] SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol - v54:[modifyText] [_UpdateTracker:9785656] Update Tracker - [Reaction:428015] SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol - v51:[modifyText]
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