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Details on Person SLC26A3,6 exchange Cl- for HCO3-

Class:Id	Reaction:427666
_displayName	SLC26A3,6 exchange Cl- for HCO3-
_doRelease	TRUE
_timestamp	2025-08-13 18:00:13
authored	[InstanceEdit:427553] Jassal, Bijay, 2009-06-23
catalystActivity	[CatalystActivity:427634] solute:inorganic anion antiporter activity of SLC26A3,6 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:427553] Jassal, Bijay, 2009-06-23
edited	[InstanceEdit:427553] Jassal, Bijay, 2009-06-23
input	[SimpleEntity:188972] Cl- [extracellular region] [SimpleEntity:111627] HCO3- [cytosol]
literatureReference	[LiteratureReference:425385] Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas [LiteratureReference:425445] Mutations of the Down-regulated in adenoma (DRA) gene cause congenital chloride diarrhoea [LiteratureReference:425434] Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family [LiteratureReference:425390] Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9
modified	[InstanceEdit:425499] Jassal, Bijay, 2009-06-04 [InstanceEdit:425676] Jassal, Bijay, 2009-06-05 [InstanceEdit:427684] Jassal, Bijay, 2009-06-23 [InstanceEdit:428053] Jassal, Bijay, 2009-06-30 [InstanceEdit:433652] Jassal, Bijay, 2009-08-24 [InstanceEdit:5627754] Jassal, Bijay, 2014-10-20 [InstanceEdit:5627819] Jassal, Bijay, 2014-10-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9963189] Stephan, Ralf, 2025-08-13
name	SLC26A3,6 exchange Cl- for HCO3- Group 2 - Cl-/HCO3- exchanger transport
output	[SimpleEntity:352022] Cl- [cytosol] [SimpleEntity:425425] HCO3- [extracellular region]
precedingEvent	[Reaction:425577] Na+-driven Cl-/HCO3- exchanger transport [Homo sapiens] [Reaction:427555] SLC26A1,2 cotransport SO4(2-), anion from extracellular region to cytosol [Homo sapiens] [Reaction:427666] SLC26A3,6 exchange Cl- for HCO3- [Homo sapiens] [Reaction:425482] SLC4A1,2,3 exchanges HCO3- for Cl- [Homo sapiens] [Reaction:8878664] SLC4A4 cotransports Na+ with 3HCO3- [Homo sapiens] [Reaction:425483] SLC4A5,7,9 cotransport Na+ with 3HCO3- [Homo sapiens]
releaseDate	2009-09-30
reviewed	[InstanceEdit:433651] He, L, 2009-08-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104961] R-HSA-427666.3
summation	[Summation:427630] The proteins responsible for the exchange of chloride (Cl-) ...
(hasEvent)	[Pathway:427601] Inorganic anion exchange by SLC26 transporters [Homo sapiens]
(normalReaction)	[FailedReaction:5627737] SLC26A3 does not exchange Cl- for HCO3- [Homo sapiens]
(precedingEvent)	[Reaction:425577] Na+-driven Cl-/HCO3- exchanger transport [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785892] Update Tracker - [Reaction:427666] SLC26A3,6 exchange Cl- for HCO3- - v51:[modifyText, removeLiteratureReference]
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No pathways have been reviewed or authored by SLC26A3,6 exchange Cl- for HCO3- (427666)