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Query author contributions in Reactome

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Details on Person SIRT1 [nucleoplasm]

Class:IdEntityWithAccessionedSequence:427531
_displayNameSIRT1 [nucleoplasm]
_timestamp2014-11-20 04:09:57
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:427509] May, B, 2009-06-23
endCoordinate747
modified[InstanceEdit:427537] May, B, 2009-06-23
[InstanceEdit:3448660] Wu, G, 2013-05-16
[InstanceEdit:3632907] Wu, G, 2013-05-28
[InstanceEdit:4085113] Orlic-Milacic, M, 2013-08-01
nameSIRT1
NAD-dependent deacetylase sirtuin-1
SIRT1_HUMAN
referenceEntity[ReferenceGeneProduct:101614] UniProt:Q96EB6 SIRT1 [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5648350] R-HSA-427531.1
startCoordinate2
(activeUnit)[CatalystActivity:427521] histone deacetylase activity of eNoSC [nucleoplasm]
[CatalystActivity:5083139] NAD-dependent protein lysine deacetylase activity of SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm]
[CatalystActivity:9859915] NAD-dependent protein lysine deacetylase activity of SIRT1:p-S90.Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:Nucleosome with H3K9acK14ac and H4K16ac:NAMPT gene [nucleoplasm]
[CatalystActivity:9960058] NAD-dependent protein lysine deacetylase activity of Ac-13K-PPARGC1A:SIRT1:RORA:BMAL1 gene [nucleoplasm]
[CatalystActivity:9961811] NAD-dependent protein lysine deacetylase activity of SIRT1:p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:Nucleosome with H3K9acK14ac and H4K16ac:NAMPT gene [nucleoplasm]
[CatalystActivity:9961881] NAD-dependent protein lysine deacetylase activity of SIRT1:p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:Nucleosome with H3K9acK14ac and H4K16ac:PER2 gene [nucleoplasm]
[CatalystActivity:9961883] NAD-dependent protein lysine deacetylase activity of SIRT1:p-S90,Ac-K538-BMAL1:p-Y451,T461,S440,S441,S446-CLOCK:Nucleosome with H3K9acH3K14ac and H4K16ac:PER2 gene [nucleoplasm]
[CatalystActivity:9961885] NAD-dependent protein lysine deacetylase activity of SIRT1:p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:Nucleosome with H3K9acK14ac and H3K16ac:SIRT1 gene [nucleoplasm]
[CatalystActivity:9961892] NAD-dependent protein lysine deacetylase activity of SIRT1:p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:Nucleosome with H3K9acK14ac and H4K16ac:SIRT1 gene [nucleoplasm]
[NegativeGeneExpressionRegulation:9815610] Negative gene expression regulation by 'ZEB1:CDH1 gene, SMARCA4:ZEB1:CDH1 gene, HDAC1,(HDAC2):TLE1:ZEB1:CDH1 gene, (SETD8:ZEB1:CDH1 gene, SIRT1:MPHOSPH8:ZEB1:CDH1 gene) [nucleoplasm]'
(hasComponent)[Complex:427510] eNoSC [nucleoplasm] [Homo sapiens]
[Complex:3371545] p-T454-DBC1:SIRT1 [nucleoplasm] [Homo sapiens]
[Complex:5082382] SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm] [Homo sapiens]
[Complex:9859865] SIRT1:p-S90.Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:Nucleosome with H3K9acK14ac and H4K16ac:NAMPT gene [nucleoplasm] [Homo sapiens]
[Complex:9859883] SIRT1:p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:Nucleosome with H3K9acK14ac and H4K16ac:NAMPT gene [nucleoplasm] [Homo sapiens]
[Complex:9860206] SIRT1:p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:Nucleosome with H3K9acK14ac and H4K16ac:PER2 gene [nucleoplasm] [Homo sapiens]
[Complex:9860210] SIRT1:p-S90,Ac-K538-BMAL1:p-Y451,T461,S440,S441,S446-CLOCK:Nucleosome with H3K9acH3K14ac and H4K16ac:PER2 gene [nucleoplasm] [Homo sapiens]
[Complex:9931121] SIRT1:MPHOSPH8:ZEB1:CDH1 gene [nucleoplasm] [Homo sapiens]
[Complex:9960092] SIRT1:p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:Nucleosome:PER2 gene [nucleoplasm] [Homo sapiens]
[Complex:9960096] PPARGC1A:SIRT1:RORA:BMAL1 gene [nucleoplasm] [Homo sapiens]
List all 28 refering instances
(hasMember)[DefinedSet:9622899] SIRT1,SIRT3 [nucleoplasm] [Homo sapiens]
(input)[Reaction:427528] Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) [Homo sapiens]
[Reaction:3371518] SIRT1 binds to HSF1 [Homo sapiens]
[Reaction:3371537] DBC1 binds SIRT1 [Homo sapiens]
[Reaction:9765850] ZEB1 recruits MPHOSPH8 (MPP8) to CDH1 gene promoter [Homo sapiens]
[Reaction:9859928] SIRT1 binds p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:Nucleosome with H3K9acK14ac and H4K16ac:NAMPT gene [Homo sapiens]
[Reaction:9860203] SIRT1 binds p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:Nucleosome with H3K9acK14ac and H4K16ac:PER2 gene [Homo sapiens]
[Reaction:9961783] SIRT1 binds p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:Nucleosome with H3K9acK14ac and H4K16ac:SIRT1 gene [Homo sapiens]
[Reaction:9961791] SIRT1 binds Ac-13K-PPARGC1A:RORA:BMAL1 gene [Homo sapiens]
[Reaction:9983406] SIRT1 binds to ORF50 promoter [Homo sapiens]
(output)[Reaction:3371467] SIRT1 deacetylates HSF1 [Homo sapiens]
[BlackBoxEvent:9854916] MITF-M-dependent SIRT1 gene expression [Homo sapiens]
[BlackBoxEvent:9958954] p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK positively regulates expression of SIRT1 [Homo sapiens]
[Reaction:9984971] SIRT1 dissociates from ORF50 promoter [Homo sapiens]
(physicalEntity)[CatalystActivity:5211232] NAD-dependent protein lysine deacetylase activity of SIRT1 [nucleoplasm]
[CatalystActivity:9626963] protein lysine deacetylase activity of SIRT1 [nucleoplasm]
(regulator)[PositiveGeneExpressionRegulation:5656490] Positive gene expression regulation by 'SIRT1 [nucleoplasm]'
[PositiveGeneExpressionRegulation:5656526] Positive gene expression regulation by 'SIRT1 [nucleoplasm]'
[PositiveRegulation:9907551] Positive regulation by 'SIRT1 [nucleoplasm]'
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No pathways have been reviewed or authored by SIRT1 [nucleoplasm] (427531)
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