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Details on Person Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA

Class:Id	Reaction:427409
_displayName	Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA
_doRelease	TRUE
_timestamp	2023-12-10 10:37:19
authored	[InstanceEdit:427381] May, B, 2009-06-19
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:427372] May, B, 2009-06-19
edited	[InstanceEdit:427381] May, B, 2009-06-19
inferredFrom	[Reaction:573336] Nucleolar Chromatin Remodeling Complex (NoRC) binds intergenic spacer of rRNA gene [Mus musculus]
input	[Complex:74977] TTF1:Sal Box [nucleoplasm] [Homo sapiens] [Complex:352501] SIN3 HDAC corepressor complex [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:205021] HDAC1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:205135] HDAC2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:212181] DNMT1 [nucleoplasm] [Homo sapiens] [Complex:427339] NoRC [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:212316] DNMT3B [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:427397] pRNA (intergenic rRNA) [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:9615889] A novel RNA binding surface of the TAM domain of TIP5/BAZ2A mediates epigenetic regulation of rRNA genes [LiteratureReference:427351] Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells
modified	[InstanceEdit:427451] May, B, 2009-06-22 [InstanceEdit:565730] May, B, 2010-04-06 [InstanceEdit:573322] May, B, 2010-04-10 [InstanceEdit:5084121] May, B, 2013-11-08 [InstanceEdit:5096482] May, B, 2013-11-10 [InstanceEdit:5219070] May, B, 2013-12-21 [InstanceEdit:5226878] May, B, 2014-01-08 [InstanceEdit:5250950] May, B, 2014-01-31 [InstanceEdit:5332992] May, B, 2014-02-18 [InstanceEdit:9032232] Orlic-Milacic, Marija, 2017-12-08 [InstanceEdit:9615893] May, Bruce, 2018-08-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9856088] May, Bruce, 2023-12-10
name	Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA Binding of Nucleolar Chromatin Remodeling Complex to Intergenic Spacer of rRNA Gene
output	[Complex:427410] NoRC:pRNA:HDAC:DNMT [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:74974] TTF1 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:74987] TTF1 binds to the Sal Box [Homo sapiens] [Reaction:74986] Elongation of pre-rRNA transcript [Homo sapiens] [BlackBoxEvent:427394] Cleavage of intergenic spacer RNA to yield fragments of 150-300 nucleotides [Homo sapiens] [BlackBoxEvent:427366] Transcription of intergenic spacer of the rRNA gene [Homo sapiens]
releaseDate	2014-03-12
reviewed	[InstanceEdit:5332991] Shiao, YH, 2014-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644413] R-HSA-427409.5
summation	[Summation:427395] As inferred from mouse cell models, the Nucleolar Remodeling...
(hasEvent)	[Pathway:427413] NoRC negatively regulates rRNA expression [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:433672] NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778992] Update Tracker - [Reaction:427409] Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA - v66:[addLiteratureReference, modifyText] [_UpdateTracker:9864089] Update Tracker - [Reaction:427409] Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA - v88:[add_removeLiteratureReference, modifyText]
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