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Details on Person TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9

Class:Id	Reaction:427336
_displayName	TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9
_doRelease	TRUE
_timestamp	2024-07-16 19:50:02
authored	[InstanceEdit:427423] May, B, 2009-06-21
catalystActivity	[CatalystActivity:427400] histone H3K9 methyltransferase activity of TTFI:Sal Box:CSB:G9a:NuRD [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:427372] May, B, 2009-06-19
edited	[InstanceEdit:427381] May, B, 2009-06-19
inferredFrom	[Reaction:573373] Ttf-I:rRNA Promoter:Ercc6:Ehmt2 complex dimethylates histone H3 at lysine-9 [Homo sapiens]
input	[SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [Complex:3211736] Chromatin [nucleoplasm] [Homo sapiens]
modified	[InstanceEdit:427427] May, B, 2009-06-21 [InstanceEdit:427453] May, B, 2009-06-22 [InstanceEdit:427487] May, B, 2009-06-23 [InstanceEdit:433756] May, B, 2009-08-25 [InstanceEdit:573322] May, B, 2010-04-10 [InstanceEdit:3211737] May, B, 2013-03-08 [InstanceEdit:5084121] May, B, 2013-11-08 [InstanceEdit:5227039] May, B, 2014-01-09 [InstanceEdit:5250950] May, B, 2014-01-31 [InstanceEdit:8856905] May, Bruce, 2016-02-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9915824] D'Eustachio, Peter, 2024-07-16
name	TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9 TTF-I;rRNA Promoter:CSB:G9a Complex Dimethylates Histone H3 at lysine-9
output	[SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [Complex:3211683] Chromatin (H3K9me2) [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:427404] Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene [Homo sapiens] [Reaction:74987] TTF1 binds to the Sal Box [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8856904] Iben, Sebastian, 2016-02-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861371] R-HSA-427336.3
summation	[Summation:427348] As inferred from mouse, EHMT2 (histone methyltransferase G9a...
(hasEvent)	[Pathway:427389] ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression [Homo sapiens]
(precedingEvent)	[Reaction:427383] CBX3 (HP1gamma) binds histone H3 dimethylated at lysine-9 [Homo sapiens]
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No pathways have been reviewed or authored by TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9 (427336)