Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person The P2X1 receptor is a rapidly-desensitized ATP-gated cation...
| Class:Id | Summation:427221 |
|---|---|
| _displayName | The P2X1 receptor is a rapidly-desensitized ATP-gated cation... |
| _timestamp | 2010-06-02 14:35:03 |
| created | [InstanceEdit:427214] Jupe, S, 2009-06-19 |
| literatureReference | [LiteratureReference:427212] ATP-induced vasodilation and purinergic receptors in the human leg: roles of nitric oxide, prostaglandins, and adenosine [LiteratureReference:427224] Overexpression of the platelet P2X1 ion channel in transgenic mice generates a novel prothrombotic phenotype [LiteratureReference:427230] The role of ADP receptors in platelet function [LiteratureReference:866438] The ATP-gated P2X1 ion channel acts as a positive regulator of platelet responses to collagen [LiteratureReference:866450] A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo [LiteratureReference:866436] ATP augments von Willebrand factor-dependent shear-induced platelet aggregation through Ca2+-calmodulin and myosin light chain kinase activation |
| modified | [InstanceEdit:866439] Jupe, S, 2010-06-01 [InstanceEdit:870198] Jupe, S, 2010-06-02 |
| text | The P2X1 receptor is a rapidly-desensitized ATP-gated cation channel with relatively high calcium permeability. It has highest expression in smooth muscle and platelets. P2X1 receptor activation cannot induce platelet aggregation but does contribute to aggregation seen in response to collagen (Oury et al. 2001; Hechler et al. 2003). The role of P2X1 is more significant under flow conditions characterized by high shear stress (Hechler et al. 2003; Oury et al. 2004). P2X1 knockout mice havereduced incidence of thrombosis of mesenteric arterioles triggered by laser-induced vessel wall injury and are resistant to the acute systemic thromboembolism induced by infusion of a mixture of collagen and adrenaline (Hechler et al. 2003). Conversely, increased systemic thrombosis has been reported in mice overexpressing the human P2X1 receptor (Oury et al. 2003). P2X1 binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, controlling sympathetic vasoconstriction in small arteries, arterioles and vas deferens. |
| (summation) | [Reaction:139855] P2X1-mediated entry of Ca++ from plasma [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by The P2X1 receptor is a rapidly-desensitized ATP-gated cation... (427221)
