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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person Diagram of Cell surface interactions at the vascular wall

Class:IdPathwayDiagram:427205
_displayNameDiagram of Cell surface interactions at the vascular wall
_timestamp2020-09-08 23:18:28
created[InstanceEdit:427204] D'Eustachio, P, 2009-06-18
height2098
modified[InstanceEdit:1679954] Wu, G, 2011-10-20
[InstanceEdit:2859694] Jupe, S, 2012-12-19
[InstanceEdit:3249423] Shamovsky, V, 2013-04-09
[InstanceEdit:3274526] Shamovsky, V, 2013-04-11
[InstanceEdit:3556808] Shamovsky, V, 2013-05-20
[InstanceEdit:3604379] Matthews, L, 2013-05-22
[InstanceEdit:3621843] Matthews, L, 2013-05-24
[InstanceEdit:5603463] Jupe, Steve, 2014-07-02
[InstanceEdit:5606983] Matthews, Lisa, 2014-07-08
[InstanceEdit:5622058] Jupe, S, 2014-09-09
[InstanceEdit:5622069] Jupe, S, 2014-09-10
[InstanceEdit:5622113] Jupe, S, 2014-09-11
[InstanceEdit:5622114] Jupe, S, 2014-09-11
[InstanceEdit:5676083] Jupe, Steve, 2015-02-19
[InstanceEdit:8849433] Matthews, Lisa, 2015-12-15
[InstanceEdit:8849440] Matthews, Lisa, 2015-12-15
[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:8870847] Garapati, Phani Vijay, 2016-05-12
[InstanceEdit:8948659] Jupe, Steve, 2016-11-15
[InstanceEdit:8948865] Jupe, Steve, 2016-11-17
[InstanceEdit:8948870] Jupe, Steve, 2016-11-17
[InstanceEdit:9606434] Jassal, Bijay, 2018-04-23
[InstanceEdit:9690529] Jassal, Bijay, 2020-06-02
[InstanceEdit:9699028] Matthews, Lisa, 2020-09-08
representedPathway[Pathway:202733] Cell surface interactions at the vascular wall [Homo sapiens]
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reactomeId="197912" position="3134 197" bounds="3109 186 50 22" textPosition="3109 186"> <Properties> <displayName>CXADR</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="80" reactomeId="198198" position="3144 282" bounds="3089 264 110 36" textPosition="3089 265" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CXADR bound to JAML</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="83" reactomeId="141051" position="127 402" bounds="75 391 104 22" textPosition="77 391"> <Properties> <displayName>PROC(200-211)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="84" reactomeId="141038" position="266 346" bounds="201 328 131 36" textPosition="206 329" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>activated thrombin:thrombomodulin</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="85" reactomeId="203105" position="68 348" bounds="12 337 113 22" textPosition="18 337"> <Properties> <displayName>Platelet Factor 4</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="86" reactomeId="171131" position="3071 35" bounds="3056 24 30 22" textPosition="3056 25" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LDL</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="87" reactomeId="203139" position="3112 77" bounds="3092 66 40 22" textPosition="3092 66"> <Properties> <displayName>OLR1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="88" reactomeId="203127" position="3145 152" bounds="3095 134 100 36" textPosition="3095 135" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>OLR1 bound to oxidized LDL</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntity id="89" reactomeId="203159" position="3129 398" bounds="3070 373 118 50" textPosition="3070 373"> <Properties> <displayName>Ligand to TREM-1 on the platelet membrane</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableProtein id="90" reactomeId="197654" position="3133 336" bounds="3108 325 50 22" textPosition="3109 325"> <Properties> <displayName>TREM1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="91" reactomeId="203154" position="3133 462" bounds="3066 444 134 36" textPosition="3066 445" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TREM-1 bound to its ligand</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="128" reactomeId="210238" position="262 220" bounds="213 209 98 22" textPosition="215 210" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PECAM1 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="133" reactomeId="210216" position="252 76" bounds="187 65 130 22" textPosition="187 66" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Integrin alphaVbeta3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="134" reactomeId="210229" position="239 156" bounds="196 131 87 50" textPosition="197 132" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Integrin alphaVbeta3:PECAM1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="142" reactomeId="113592" position="398 211" bounds="378 196 40 30" textPosition="383 200"> <Properties> <displayName>ATP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="143" reactomeId="29370" position="397 292" bounds="377 277 41 30" textPosition="381 281" /> <org.gk.render.RenderableComplex id="144" reactomeId="211539" position="262 261" bounds="214 243 97 36" textPosition="216 244" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-Y663,Y686-PECAM1 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="145" reactomeId="211064" position="506 252" bounds="443 234 126 36" textPosition="446 234"> <Properties> <displayName>Src family tyrosine kinases (SFKs)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="150" reactomeId="197940" position="955 1775" bounds="928 1764 54 22" textPosition="930 1764"> <Properties> <displayName>INPP5D</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="151" reactomeId="210007" position="1076 1783" bounds="1028 1765 97 36" textPosition="1030 1765"> <Properties> <displayName>p-Y663,Y686-PECAM1(27-?)</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.16494845360824742" relativeY="0.0" label="P" description="Tyr" trackId="0" reactomeId="210025" /> <org.gk.render.RenderableFeature relativeX="0.32989690721649484" relativeY="0.0" label="P" description="Tyr" trackId="0" reactomeId="210018" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="152" reactomeId="210218" position="956 1986" bounds="904 1968 105 36" textPosition="904 1969" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PECAM-1:SHIP1 complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="154" reactomeId="210219" position="1079 1985" bounds="1025 1967 109 36" textPosition="1026 1968" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PECAM-1:SHP-2 complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="156" reactomeId="202320" position="704 1844" bounds="681 1833 47 22" textPosition="682 1833"> <Properties> <displayName>PLCG1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="157" reactomeId="210240" position="704 1986" bounds="645 1968 118 36" textPosition="648 1969" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PECAM-1:PLC gamma1 complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="159" reactomeId="197938" position="837 1784" bounds="813 1773 48 22" textPosition="814 1773"> <Properties> <displayName>PTPN6</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="160" reactomeId="210221" position="835 1987" bounds="781 1969 109 36" textPosition="782 1970" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PECAM-1:SHP-1 complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="162" reactomeId="204475" position="840 681" bounds="819 670 42 22" textPosition="821 670"> <Properties> <displayName>PPIL2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="163" reactomeId="204478" position="733 642" bounds="716 631 34 22" textPosition="718 631"> <Properties> <displayName>BSG</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="164" reactomeId="204498" position="733 757" bounds="674 739 118 36" textPosition="675 740" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CyP60 complexed with Basigin</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="170" reactomeId="17963" position="814 646" bounds="720 503 188 286" textPosition="768 709" bgColor="250 240 240" lineColor="255 153 102" insets="730 513 168 266"> <Properties> <displayName>Golgi lumen</displayName> </Properties> <Components> <Component id="162" /> <Component id="163" /> <Component id="164" /> <Component id="187" /> <Component id="188" /> <Component id="161" /> <Component id="186" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="180" reactomeId="197673" position="266 856" bounds="249 845 34 22" textPosition="251 845" /> <org.gk.render.RenderableComplex id="181" reactomeId="204594" position="259 799" bounds="223 788 73 22" textPosition="226 789" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>BSG dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="187" reactomeId="204504" position="852 602" bounds="832 591 41 22" textPosition="832 591"> <Properties> <displayName>CAV1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="188" reactomeId="204550" position="734 532" bounds="668 514 132 36" textPosition="668 515" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Caveolin-1 bound to Basigin</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="191" reactomeId="204480" position="253 1031" bounds="221 1020 65 22" textPosition="224 1021" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>BSG:PPIA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="192" reactomeId="190915" position="115 997" bounds="102 986 26 22" textPosition="103 986"> <Properties> <displayName>HS</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="198" reactomeId="204438" position="259 1068" bounds="242 1057 34 22" textPosition="244 1057"> <Properties> <displayName>SPN</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="199" reactomeId="204467" position="258 1100" bounds="227 1089 63 22" textPosition="230 1090" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>BSG:SPN</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="201" reactomeId="375064" position="140 897" bounds="87 886 107 22" textPosition="89 886"> <Properties> <displayName>MMP1(100-469)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="202" reactomeId="375089" position="227 934" bounds="175 916 105 36" textPosition="176 917" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>BSG:MMP1(100-469)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="204" reactomeId="375083" position="253 1149" bounds="191 1124 124 50" textPosition="194 1124" bgColor="204 255 255"> <Properties> <displayName>Mannose-carrying cell recognition molecules</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="205" reactomeId="375090" position="252 1231" bounds="193 1199 119 64" textPosition="196 1200" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Basigin:Mannose-carrying cell recognition molecules</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="207" reactomeId="204466" position="260 1308" bounds="212 1283 97 50" textPosition="217 1283" bgColor="204 255 255"> <Properties> <displayName>Integrin alpha3beta1, alpha6beta1</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="208" reactomeId="204472" position="261 1373" bounds="213 1348 97 50" textPosition="218 1349" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>BSG:Integrin alpha3beta1, alpha6beta1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="214" reactomeId="374008" position="262 1439" bounds="207 1414 111 50" textPosition="207 1414"> <Properties> <displayName>Monocarboxylate Transporter Set (MCT)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="215" reactomeId="204396" position="257 1492" bounds="222 1481 70 22" textPosition="224 1482" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>BSG:MCTs</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="217" reactomeId="375088" position="259 1531" bounds="203 1520 112 22" textPosition="205 1520" bgColor="204 255 255"> <Properties> <displayName>CD98hc complex</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="218" reactomeId="375086" position="258 1573" bounds="203 1555 110 36" textPosition="206 1556" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Basigin:CD98hc complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="220" reactomeId="197701" position="111 1587" bounds="78 1576 66 22" textPosition="81 1570"> <Properties> <displayName>CEACAM1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="221" reactomeId="352620" position="124 1652" bounds="77 1634 94 36" textPosition="77 1635" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Cis-CEACAM1 homodimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="223" reactomeId="210228" position="272 1620" bounds="219 1602 107 36" textPosition="219 1603" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Trans CEACAM1 homodimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="225" reactomeId="202719" position="113 1779" bounds="47 1747 132 64" textPosition="46 1747"> <Properties> <displayName>Neutrophil CEACAMs affecting integrin binding to fibronectin</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="226" reactomeId="202716" position="276 1775" bounds="233 1757 86 36" textPosition="236 1758" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CEACAM heterodimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="228" reactomeId="432297" position="649 75" bounds="587 57 124 37" textPosition="589 59" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>GPVI:FceRI gamma:FYN:LYN</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="229" reactomeId="434812" position="789 75" bounds="729 50 121 50" textPosition="730 51" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>GPVI:FceRI gamma:FYN:LYN:Collagen type I</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntity id="231" reactomeId="1474201" position="597 24" bounds="532 13 131 22" textPosition="534 13"> <Properties> <displayName>Collagen type I fibril</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableProtein id="234" reactomeId="2870223" position="3129 709" bounds="3110 698 39 22" textPosition="3112 698" /> <org.gk.render.RenderableComplex id="236" reactomeId="2870225" position="3137 746" bounds="3090 730 95 33" textPosition="3097 728" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>2xSELE ligands:SELE</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="237" reactomeId="3274516" position="3135 667" bounds="3097 651 77 32" textPosition="3110 650"> <Properties> <displayName>SELE ligands</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="246" reactomeId="3325587" position="2591 74" bounds="2570 63 42 22" textPosition="2571 63"> <Properties> <displayName>CD84</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="247" reactomeId="173646" position="197 976" bounds="179 965 36 22" textPosition="180 965"> <Properties> <displayName>PPIA</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableCompartment id="433" reactomeId="70101" position="70 1690" bounds="19 1548 102 285" textPosition="32 1706" bgColor="250 240 240" lineColor="255 153 102" insets="29 1557 82 268"> <Components> <Component id="225" /> <Component id="220" /> <Component id="221" /> <Component id="230" /> <Component id="219" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="434" reactomeId="5603321" position="264 300" bounds="209 289 111 22" textPosition="212 290" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PROCR:Protein C</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="435" reactomeId="5603469" position="273 395" bounds="215 377 116 36" textPosition="218 378" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PROCR:Activated protein C</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="475" reactomeId="2130505" position="381 1983" bounds="339 1972 84 22" textPosition="341 1973" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CD74 trimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="476" reactomeId="5676088" position="467 1983" bounds="432 1972 70 22" textPosition="433 1973" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MIF trimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="477" reactomeId="5676093" position="573 1984" bounds="516 1966 114 36" textPosition="519 1967" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MIF trimer:CD74 trimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="479" reactomeId="8870734" position="2008 79" bounds="1960 61 96 36" textPosition="1961 61"> <Properties> <displayName>Proteoglycans,TGFB1</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="480" reactomeId="8870760" position="2046 19" bounds="2028 8 37 22" textPosition="2029 8"> <Properties> <displayName>PSGs</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="481" reactomeId="8870733" position="2129 78" bounds="2068 60 122 36" textPosition="2070 61" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PSGs:Proteoglycan,TGFB1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="657" reactomeId="983669" position="3140 1754" bounds="3085 1743 110 22" textPosition="3087 1744" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>IgM Heavy Chain</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="658" reactomeId="983678" position="3135 1674" bounds="3083 1649 105 50" textPosition="3084 1650" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Pre-B Cell Surrogate Light Chain</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="659" reactomeId="983671" position="3133 1806" bounds="3067 1781 132 50" textPosition="3067 1782" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Immunoglobulin Mu with Surrogate Light Chain</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="661" reactomeId="8858031" position="2602 2051" bounds="2549 2040 106 22" textPosition="2558 2041" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>2xIgA:JCHAIN</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="662" reactomeId="8858029" position="2607 1990" bounds="2582 1979 51 22" textPosition="2583 1979"> <Properties> <displayName>FCAMR</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="663" reactomeId="8858512" position="2688 1973" bounds="2645 1944 86 59" textPosition="2661 1954" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>FCAMR:2xIgA:JCHAIN</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="665" reactomeId="416989" position="3017 1877" bounds="2995 1866 45 22" textPosition="2996 1866"> <Properties> <displayName>PICK1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="666" reactomeId="400337" position="3132 1878" bounds="3105 1867 55 22" textPosition="3106 1867"> <Properties> <displayName>TSPAN7</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="667" reactomeId="8858433" position="3135 1919" bounds="3088 1908 95 22" textPosition="3090 1909" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TSPAN7:PICK1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="669" reactomeId="8867216" position="2883 2037" bounds="2837 2019 92 36" textPosition="2837 2019"> <Properties> <displayName>eba-175,ebl1,eba-140</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="670" reactomeId="8867165" position="2891 1985" bounds="2849 1969 85 32" textPosition="2853 1968"> <Properties> <displayName>GYPA,GYPB,GYPC</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="671" reactomeId="8867180" position="3071 1980" bounds="3009 1955 125 50" textPosition="3012 1956" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>GYPA,GYPB,GYPC:eba-175,ebl1,eba-140</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="689" reactomeId="70101" position="2834 2060" bounds="2727 2030 215 60" textPosition="2738 2042" bgColor="250 240 240" lineColor="255 153 102" insets="2735 2039 197 39"> <Components> <Component id="669" /> <Component id="692" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="691" reactomeId="375068" position="2769 1983" bounds="2744 1972 51 22" textPosition="2745 1972"> <Properties> <displayName>EPCAM</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="692" reactomeId="8867172" position="2777 2029" bounds="2732 2018 90 22" textPosition="2734 2019" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>EPCAM dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="694" reactomeId="8862085" position="3138 1051" bounds="3118 1040 41 22" textPosition="3118 1040"> <Properties> <displayName>CD99</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="695" reactomeId="8867207" position="3132 1091" bounds="3105 1080 55 22" textPosition="3105 1080"> <Properties> <displayName>CD99L2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="696" reactomeId="8867105" position="3149 1137" bounds="3104 1121 90 32" textPosition="3122 1118" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CD99:CD99L2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="698" reactomeId="8867228" position="2394 1988" bounds="2355 1970 78 36" textPosition="2359 1970"> <Properties> <displayName>CEACAM1,3,5,6</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="699" reactomeId="8867104" position="2408 2044" bounds="2366 2033 85 22" textPosition="2368 2033"> <Properties> <displayName>opa proteins</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="700" reactomeId="8867145" position="2510 1984" bounds="2457 1964 107 40" textPosition="2458 1969" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CEACAM1,3,5,6:opa proteins</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="701" reactomeId="70101" position="2390 2061" bounds="2292 2036 196 50" textPosition="2308 2039" bgColor="250 240 240" lineColor="255 153 102" insets="2302 2047 177 28"> <Properties> <displayName>cytosol</displayName> </Properties> <Components> <Component id="699" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableEntitySet id="720" reactomeId="5634815" position="3137 1515" bounds="3098 1497 79 36" textPosition="3098 1497"> <Properties> <displayName>TNFRSF10A,TNFRSF10B</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="721" reactomeId="5633374" position="3139 1562" bounds="3099 1548 81 29" textPosition="3102 1552"> <Properties> <displayName>TNFRSF10D</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="722" reactomeId="5635735" position="3137 1606" bounds="3089 1588 96 36" textPosition="3092 1588"> <Properties> <displayName>TNFRSF10A,B:TNFRSF10D</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="730" reactomeId="9606442" position="3136 1189" bounds="3082 1178 108 22" textPosition="3089 1178"> <Properties> <displayName>SELE,SELL,SELP</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="733" reactomeId="9606393" position="3222 1224" bounds="3200 1209 45 30" textPosition="3205 1213"> <Properties> <displayName>sLeX</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="734" reactomeId="9606443" position="3137 1290" bounds="3080 1272 115 36" textPosition="3088 1273" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>sLeX:SELE,SELL,SELP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="805" reactomeId="9606441" position="3242 1356" bounds="3191 1345 102 22" textPosition="3197 1345"> <Properties> <displayName>LeY,sLeA,sLeX</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="807" reactomeId="9606447" position="3132 1435" bounds="3078 1417 109 36" textPosition="3085 1418" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LeY,sLeX,sLeA:SELE</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="809" reactomeId="2870223" position="3132 1344" bounds="3113 1333 39 22" textPosition="3115 1333"> <Properties> <displayName>SELE</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProteinDrug id="817" reactomeId="9679737" position="1649 15" bounds="1601 4 96 22" textPosition="1609 4" bgColor="184 154 230" fgColor="161 1 2" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>natalizumab</displayName> </Properties> </org.gk.render.RenderableProteinDrug> <org.gk.render.RenderableComplex id="818" reactomeId="9679842" position="1762 75" bounds="1714 57 96 36" textPosition="1719 58" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>ITGA4:ITGB1:natalizumab</displayName> </Properties> </org.gk.render.RenderableComplex> </Nodes> <Edges> <org.gk.render.RenderableReaction id="92" reactomeId="204873" points="1200 1904, 1201 1933, 1201 1966" position="1201 1933" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="22" points="1184 1884" /> <Input id="14" points="1706 1852" /> </Inputs> <Outputs> <Output id="24" /> </Outputs> <Properties> <displayName>Interaction of Tie2 and Shp2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="93" reactomeId="210881" points="256 614, 218 630, 242 658" position="218 630" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="26" stoichiometry="2" /> </Inputs> <Outputs> <Output id="4" /> </Outputs> <Properties> <displayName>Dimerization of Tie2/Ang1 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="94" reactomeId="204798" points="1652 1873, 1653 1947, 1653 1974" position="1653 1947" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="14" points="1706 1859" /> <Input id="32" points="1652 1786" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> <Properties> <displayName>Interaction of Tie2 and p85 of PI3K</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="95" reactomeId="210872" points="337 682, 337 706, 337 729" position="337 706" lineWidth="1.0"> <Inputs> <Input id="11" stoichiometry="12" points="366 659" /> <Input id="4" points="304 677" /> </Inputs> <Outputs> <Output id="25" stoichiometry="12" points="372 743" /> <Output id="3" points="319 733" /> </Outputs> <Catalysts> <Catalyst id="26" points="324 600, 411 600, 411 706" /> </Catalysts> <Properties> <displayName>Trans-phosphorylation of Tie2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="96" reactomeId="204773" points="1311 1777, 1310 1872, 1310 1963" position="1310 1872" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="14" points="1706 1840" /> <Input id="18" points="1311 1679" /> </Inputs> <Outputs> <Output id="12" /> </Outputs> <Properties> <displayName>Interaction of Tie2 and Grb7</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="97" reactomeId="210974" points="2019 1932, 2051 1933, 2136 1961" position="2051 1933" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2" points="1998 1916" /> <Input id="17" points="1972 1972" /> </Inputs> <Outputs> <Output id="10" /> </Outputs> <Properties> <displayName>Interaction of SOS-1 to Tie2 bound Grb2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="98" reactomeId="204861" points="1833 1901, 1833 1935, 1825 1965" position="1833 1935" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="14" points="1782 1869" /> <Input id="30" points="1833 1815" /> </Inputs> <Outputs> <Output id="29" /> </Outputs> <Properties> <displayName>Interaction of Tie2 and Shc1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="99" reactomeId="204850" points="1524 1861, 1524 1906, 1525 1966" position="1524 1906" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1" points="1520 1697" /> <Input id="14" points="1706 1850" /> </Inputs> <Outputs> <Output id="13" /> </Outputs> <Properties> <displayName>Interaction of Tie2 and Dok-2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="100" reactomeId="210977" points="2160 1920, 2188 1919, 2220 1919" position="2188 1919" lineWidth="1.0"> <Inputs> <Input id="15" points="2146 1913" /> <Input id="8" points="2096 1970" /> </Inputs> <Outputs> <Output id="27" points="2231 1905" /> <Output id="20" points="2286 1972" /> </Outputs> <Catalysts> <Catalyst id="10" points="2190 1957" /> </Catalysts> <Properties> <displayName>Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="101" reactomeId="204779" points="186 579, 185 606, 233 602" position="185 606" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="31" points="259 449" /> <Input id="16" points="131 580" /> </Inputs> <Outputs> <Output id="26" /> </Outputs> <Properties> <displayName>Interaction of Tie2 with Ang1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="102" reactomeId="204813" points="1412 1852, 1411 1928, 1412 1957" position="1411 1928" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="23" points="1411 1651" /> <Input id="14" points="1706 1848" /> </Inputs> <Outputs> <Output id="9" /> </Outputs> <Properties> <displayName>Interaction of Tie2 and Grb14</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="103" reactomeId="204871" points="1920 1873, 1921 1942, 1950 1972" position="1921 1942" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="21" points="1920 1835" /> <Input id="14" points="1808 1855" /> </Inputs> <Outputs> <Output id="17" /> </Outputs> <Properties> <displayName>Interaction of Tie2 and Grb2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="104" reactomeId="204863" points="166 530, 166 555, 237 551" position="166 555" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="7" points="128 530" /> <Input id="31" points="254 449" /> </Inputs> <Outputs> <Output id="19" /> </Outputs> <Properties> <displayName>Interaction of Tie2 with Ang2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="105" reactomeId="204824" points="159 456, 159 489, 244 500" position="159 489" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="28" points="136 454" /> <Input id="31" points="247 438" /> </Inputs> <Outputs> <Output id="6" /> </Outputs> <Properties> <displayName>Interaction of Tie2 and Ang4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="106" reactomeId="114577" points="683 41, 715 39, 737 47" position="715 39" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="231" points="652 38" /> <Input id="228" points="667 54" /> </Inputs> <Outputs> <Output id="229" /> </Outputs> <Properties> <displayName>Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="107" reactomeId="202727" points="986 137, 1110 137, 1138 98" position="1110 137" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="36" points="927 95" /> <Input id="37" points="981 91" /> </Inputs> <Outputs> <Output id="38" /> </Outputs> <Properties> <displayName>Integrin alphaMbeta2 (MAC1) binds JAM3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="108" reactomeId="202721" points="1356 177, 1423 177, 1556 88" position="1423 177" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="37" points="1004 82" /> <Input id="39" points="1411 88" /> </Inputs> <Outputs> <Output id="40" /> </Outputs> <Properties> <displayName>JAM2 binds JAM3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="109" reactomeId="202706" points="1760 158, 1760 156, 1847 103" position="1760 156" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="40" points="1597 88" /> <Input id="41" points="1679 91" /> </Inputs> <Outputs> <Output id="42" /> </Outputs> <Inhibitors> <Inhibitor id="818" points="1761 96" /> </Inhibitors> <Properties> <displayName>Integrin alpha4beta1 binds JAM2:JAM3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="110" reactomeId="202726" points="2316 89, 2312 131, 2257 92" position="2312 131" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="43" stoichiometry="2" /> </Inputs> <Outputs> <Output id="44" /> </Outputs> <Properties> <displayName>F11R dimerises</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="111" reactomeId="202718" points="2421 121, 2496 122, 2503 100" position="2496 122" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="45" points="2413 94" /> <Input id="43" points="2340 89" /> </Inputs> <Outputs> <Output id="46" /> </Outputs> <Properties> <displayName>Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="112" reactomeId="202704" points="1274 138, 1322 139, 1337 103" position="1322 139" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="37" points="1004 81" /> <Input id="48" points="1260 93" /> </Inputs> <Outputs> <Output id="49" /> </Outputs> <Properties> <displayName>Integrin alphaXbeta2 binds JAM3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="113" reactomeId="202710" points="357 1680, 358 1724, 332 1725" position="358 1724" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="52" points="236 1689" /> <Input id="53" points="300 1665" /> </Inputs> <Outputs> <Output id="54" /> </Outputs> <Properties> <displayName>MERTK receptor binds ligands (Gas6 or Protein S)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="114" reactomeId="202713" points="2600 60, 2622 39, 2650 61" position="2622 39" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="246" stoichiometry="2" /> </Inputs> <Outputs> <Output id="56" /> </Outputs> <Properties> <displayName>CD84 homodimerises</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="115" reactomeId="202724" points="3044 545, 3045 608, 3087 609" position="3045 608" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="57" stoichiometry="2" points="3100 553" /> <Input id="58" points="3097 525" /> </Inputs> <Outputs> <Output id="59" /> </Outputs> <Properties> <displayName>P-selectin binds P-selectin ligand</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="116" reactomeId="202709" points="1428 60, 1451 39, 1475 59" position="1451 39" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="39" stoichiometry="2" /> </Inputs> <Outputs> <Output id="60" /> </Outputs> <Properties> <displayName>JAM2 dimerises</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="117" reactomeId="202731" points="994 63, 1020 45, 1044 57" position="1020 45" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="37" stoichiometry="2" /> </Inputs> <Outputs> <Output id="61" /> </Outputs> <Properties> <displayName>JAM3 dimerises</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="118" reactomeId="202702" points="456 116, 507 117, 522 87" position="507 117" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="62" points="393 90" /> <Input id="63" points="443 88" /> </Inputs> <Outputs> <Output id="64" /> </Outputs> <Properties> <displayName>CD177 binds PECAM-1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="119" reactomeId="202703" points="2869 37, 2901 36, 2947 55" position="2901 36" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="65" points="2805 61" /> <Input id="66" points="2876 62" /> </Inputs> <Outputs> <Output id="67" /> </Outputs> <Properties> <displayName>CD47 binds SIRP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="120" reactomeId="202722" points="3069 939, 3068 1007, 3097 1009" position="3068 1007" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="68" points="3111 956" /> <Input id="69" points="3112 921" /> </Inputs> <Outputs> <Output id="70" /> </Outputs> <Properties> <displayName>CD48 binds CD244</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="121" reactomeId="202714" points="3084 817, 3084 851, 3112 860" position="3084 851" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="71" points="3118 798" /> <Input id="72" points="3115 823" /> </Inputs> <Outputs> <Output id="73" /> </Outputs> <Properties> <displayName>CD58 binds CD2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="122" reactomeId="202723" points="266 1877, 264 1908, 265 1944" position="264 1908" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="74" points="269 1850" /> <Input id="75" points="220 1861" /> <Input id="76" points="239 1883" /> </Inputs> <Outputs> <Output id="77" /> </Outputs> <Activators> <Activator id="226" points="240 1796, 135 1846, 133 1910" /> </Activators> <Properties> <displayName>Integrin alpha5beta1 binds FN1 dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="123" reactomeId="199093" points="3062 228, 3064 278, 3086 279" position="3064 278" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="47" points="3107 235" /> <Input id="78" points="3106 207" /> </Inputs> <Outputs> <Output id="80" /> </Outputs> <Properties> <displayName>CXADR binds to AMICA1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="124" reactomeId="141040" points="206 308, 164 316, 163 347, 163 374" position="163 347" lineWidth="1.0"> <Inputs> <Input id="434" /> </Inputs> <Outputs> <Output id="435" points="212 383" /> <Output id="83" points="141 388" /> </Outputs> <Catalysts> <Catalyst id="84" points="198 346" /> </Catalysts> <Activators> <Activator id="85" points="131 347" /> </Activators> <Properties> <displayName>Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="125" reactomeId="203130" points="3072 118, 3072 150, 3092 150" position="3072 150" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="86" points="3071 49" /> <Input id="87" stoichiometry="2" points="3101 91" /> </Inputs> <Outputs> <Output id="88" /> </Outputs> <Properties> <displayName>OLR1 binds to oxidized LDL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="126" reactomeId="203156" points="3026 355, 3027 457, 3063 458" position="3027 457" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="89" points="3067 373" /> <Input id="90" points="3105 340" /> </Inputs> <Outputs> <Output id="91" /> </Outputs> <Properties> <displayName>Platelet-derived TREM-1 ligand binds to TREM-1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="127" reactomeId="210285" points="369 90, 366 181, 291 206" position="366 181" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="62" stoichiometry="2" /> </Inputs> <Outputs> <Output id="128" /> </Outputs> <Properties> <displayName>Trans-homophilic interaction of PECAM-1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="132" reactomeId="210304" points="310 108, 310 153, 286 154" position="310 153" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="133" points="271 90" /> <Input id="62" points="349 90" /> </Inputs> <Outputs> <Output id="134" /> </Outputs> <Properties> <displayName>Interaction of integrin alphaVbeta3 with PECAM1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="141" reactomeId="210291" points="350 228, 350 251, 350 268" position="350 251" lineWidth="1.0"> <Inputs> <Input id="128" points="314 224" /> <Input id="142" stoichiometry="4" points="375 218" /> </Inputs> <Outputs> <Output id="143" stoichiometry="4" points="374 281" /> <Output id="144" points="314 264" /> </Outputs> <Catalysts> <Catalyst id="145" points="437 251" /> </Catalysts> <Properties> <displayName>Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="149" reactomeId="210290" points="957 1866, 957 1925, 956 1965" position="957 1925" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="150" points="955 1789" /> <Input id="151" points="1050 1804" /> </Inputs> <Outputs> <Output id="152" /> </Outputs> <Properties> <displayName>Interaction of PECAM-1 and SHIP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="153" reactomeId="210294" points="1077 1886, 1078 1920, 1078 1964" position="1078 1920" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="151" points="1076 1804" /> <Input id="22" points="1146 1874" /> </Inputs> <Outputs> <Output id="154" /> </Outputs> <Properties> <displayName>Interaction of PECAM-1 and SHP-2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="155" reactomeId="210283" points="704 1887, 703 1927, 703 1965" position="703 1927" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="156" points="704 1858" /> <Input id="151" points="1025 1796" /> </Inputs> <Outputs> <Output id="157" /> </Outputs> <Properties> <displayName>Interaction of PECAM-1 and PLC gamma1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="158" reactomeId="210277" points="835 1879, 834 1925, 834 1966" position="834 1925" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="159" points="836 1798" /> <Input id="151" points="1030 1804" /> </Inputs> <Outputs> <Output id="160" /> </Outputs> <Properties> <displayName>Interaction of PECAM-1 and SHP-1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="161" reactomeId="204500" points="732 681, 733 703, 733 736" position="733 703" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="162" points="816 681" /> <Input id="163" points="732 656" /> </Inputs> <Outputs> <Output id="164" /> </Outputs> <Properties> <displayName>CyP60 chaperones Basigin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="179" reactomeId="204600" points="286 846, 332 821, 295 813" position="332 821" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="180" stoichiometry="2" /> </Inputs> <Outputs> <Output id="181" /> </Outputs> <Properties> <displayName>Basigin homodimerises</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="186" reactomeId="204549" points="733 602, 734 585, 734 553" position="734 585" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="163" points="733 628" /> <Input id="187" points="829 602" /> </Inputs> <Outputs> <Output id="188" /> </Outputs> <Properties> <displayName>Caveolin-1 binds Basigin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="189" reactomeId="204485" points="329 974, 314 996, 272 1017" position="314 996" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="180" points="282 870, 329 897" /> <Input id="247" points="218 975" /> </Inputs> <Outputs> <Output id="191" /> </Outputs> <Activators> <Activator id="192" points="131 996" /> </Activators> <Properties> <displayName>Basigin binds CyPA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="197" reactomeId="204465" points="338 1067, 317 1100, 293 1100" position="317 1100" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="198" points="279 1067" /> <Input id="180" points="286 865, 338 895" /> </Inputs> <Outputs> <Output id="199" /> </Outputs> <Properties> <displayName>Basigin interacts with CD43</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="200" reactomeId="375135" points="317 894, 307 932, 283 932" position="307 932" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="201" points="197 896" /> <Input id="180" points="280 870" /> </Inputs> <Outputs> <Output id="202" /> </Outputs> <Properties> <displayName>Basigin binds Matrix metalloproteinase-1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="203" reactomeId="375133" points="352 1149, 337 1230, 315 1230" position="337 1230" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="204" points="321 1149" /> <Input id="180" points="286 863, 352 896" /> </Inputs> <Outputs> <Output id="205" /> </Outputs> <Properties> <displayName>Basigin binds Mannose-carrying cell recognition molecules</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="206" reactomeId="204434" points="366 1308, 345 1373, 313 1373" position="345 1373" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="207" points="315 1308" /> <Input id="180" points="286 863, 365 898" /> </Inputs> <Outputs> <Output id="208" /> </Outputs> <Properties> <displayName>BSG (basigin) binds Integrin alpha3beta1, alpha6beta1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="213" reactomeId="204392" points="384 1439, 374 1491, 295 1491" position="374 1491" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="180" stoichiometry="2" points="286 861, 384 897" /> <Input id="214" stoichiometry="2" points="324 1439" /> </Inputs> <Outputs> <Output id="215" /> </Outputs> <Properties> <displayName>Basigin binds MCT1, MCT3 and MCT4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="216" reactomeId="375131" points="405 1527, 337 1568, 316 1569" position="337 1568" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="217" points="321 1529" /> <Input id="180" points="286 859, 406 883" /> </Inputs> <Outputs> <Output id="218" /> </Outputs> <Properties> <displayName>Basigin binds CD98 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="219" reactomeId="210301" points="92 1601, 59 1618, 89 1631" position="59 1618" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="220" stoichiometry="2" /> </Inputs> <Outputs> <Output id="221" /> </Outputs> <Properties> <displayName>CEACAM1 cis-homo dimers</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="222" reactomeId="210293" points="147 1595, 189 1607, 216 1611" position="189 1607" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="220" stoichiometry="2" /> </Inputs> <Outputs> <Output id="223" /> </Outputs> <Properties> <displayName>Trans-homophilic interaction of CEACAM1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="224" reactomeId="202717" points="185 1777, 213 1777, 230 1776" position="213 1777" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="225" stoichiometry="2" /> </Inputs> <Outputs> <Output id="226" /> </Outputs> <Properties> <displayName>Heterodimerization of CEACAMs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="230" points="111 1601, 112 1741" position="111 1671" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="220" /> </Inputs> <Outputs> <Output id="225" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="232" reactomeId="2870221" points="3062 697, 3061 745, 3087 745" position="3061 745" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="234" points="3107 705" /> <Input id="237" stoichiometry="2" points="3091 682" /> </Inputs> <Outputs> <Output id="236" /> </Outputs> <Properties> <displayName>E-selectin binds E-selectin ligand</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="239" points="3130 571, 3134 645" position="3132 608" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="57" /> </Inputs> <Outputs> <Output id="237" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="474" reactomeId="5676133" points="452 1950, 503 1949, 537 1963" position="503 1949" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="475" points="404 1969" /> <Input id="476" points="462 1969" /> </Inputs> <Outputs> <Output id="477" /> </Outputs> <Properties> <displayName>CD74 binds MIF</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="478" reactomeId="8870732" points="2098 30, 2098 30, 2117 57" position="2098 30" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="479" points="2041 55" /> <Input id="480" points="2071 22" /> </Inputs> <Outputs> <Output id="481" /> </Outputs> <Properties> <displayName>PSGs bind proteoglycans and TGF-beta1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="656" reactomeId="8858498" points="3046 1720, 3046 1760, 3085 1778" position="3046 1760" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="657" stoichiometry="2" points="3109 1740" /> <Input id="658" stoichiometry="2" points="3086 1702" /> </Inputs> <Outputs> <Output id="659" /> </Outputs> <Properties> <displayName>SL (surrogate light chain) binds IgH to form pre-BCR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="660" reactomeId="8858428" points="2623 2019, 2648 2019, 2662 2006" position="2648 2019" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="661" points="2609 2037" /> <Input id="662" points="2613 2004" /> </Inputs> <Outputs> <Output id="663" /> </Outputs> <Properties> <displayName>FCAMR binds IgA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="664" reactomeId="8858435" points="3064 1894, 3063 1920, 3085 1919" position="3063 1920" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="665" points="3043 1885" /> <Input id="666" points="3102 1884" /> </Inputs> <Outputs> <Output id="667" /> </Outputs> <Properties> <displayName>TSPAN7 binds PICK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="668" reactomeId="8867098" points="2957 2020, 2982 2019, 3013 2008" position="2982 2019" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="669" points="2935 2026" /> <Input id="670" points="2921 2007" /> </Inputs> <Outputs> <Output id="671" /> </Outputs> <Properties> <displayName>Glycophorins bind plasmodium falciparum Ags</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="690" reactomeId="8867240" points="2798 1992, 2826 2004, 2798 2015" position="2826 2004" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="691" stoichiometry="2" /> </Inputs> <Outputs> <Output id="692" /> </Outputs> <Properties> <displayName>EPCAM binds itself to form homotypic cell adhesion</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="693" reactomeId="8867097" points="3077 1068, 3075 1129, 3101 1132" position="3075 1129" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="694" points="3115 1056" /> <Input id="695" points="3105 1077" /> </Inputs> <Outputs> <Output id="696" /> </Outputs> <Properties> <displayName>CD99 binds CD99L2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="697" reactomeId="8867135" points="2441 2018, 2476 2018, 2490 2007" position="2476 2018" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="698" points="2422 2012" /> <Input id="699" points="2421 2027" /> </Inputs> <Outputs> <Output id="700" /> </Outputs> <Properties> <displayName>CEACAM1,3,5,6 bind opa proteins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="719" reactomeId="5635741" points="3057 1551, 3053 1605, 3083 1605" position="3053 1605" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="721" stoichiometry="2" points="3096 1556" /> <Input id="720" points="3092 1532" /> </Inputs> <Outputs> <Output id="722" /> </Outputs> <Properties> <displayName>TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="729" reactomeId="9606446" points="3135 1240, 3136 1240, 3136 1269" position="3136 1240" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="730" points="3135 1206" /> <Input id="733" points="3197 1228" /> </Inputs> <Outputs> <Output id="734" /> </Outputs> <Properties> <displayName>sLeX binds SELE,SELL,SELP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="804" reactomeId="9606436" points="3132 1381, 3131 1381, 3131 1414" position="3131 1381" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="805" points="3193 1373" /> <Input id="809" points="3132 1358" /> </Inputs> <Outputs> <Output id="807" /> </Outputs> <Properties> <displayName>SELE binds LeY,sLeX,sLeA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="816" reactomeId="9679740" points="1710 43, 1711 42, 1734 54" position="1711 42" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="817" points="1672 29" /> <Input id="41" points="1682 61" /> </Inputs> <Outputs> <Output id="818" /> </Outputs> <Properties> <displayName>ITGA4:ITGB1 binds natalizumab</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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