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Details on Person Diagram of Dissolution of Fibrin Clot

Class:IdPathwayDiagram:427162
_displayNameDiagram of Dissolution of Fibrin Clot
_timestamp2022-05-11 13:54:46
created[InstanceEdit:427163] D'Eustachio, P, 2009-06-17
height893
modified[InstanceEdit:499967] Jupe, S, 2010-01-29
[InstanceEdit:1381834] Jupe, S, 2011-07-06
[InstanceEdit:3063318] Gillespie, ME, 2013-02-06
[InstanceEdit:4127464] Gillespie, ME, 2013-08-14
[InstanceEdit:5606982] Matthews, Lisa, 2014-07-08
[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:9645116] Wu, G, 2019-05-03
[InstanceEdit:9724780] Jassal, Bijay, 2021-03-25
[InstanceEdit:9724935] Jassal, Bijay, 2021-03-26
[InstanceEdit:9725650] Jassal, Bijay, 2021-03-30
[InstanceEdit:9725672] Jassal, Bijay, 2021-03-31
[InstanceEdit:9725913] Jassal, Bijay, 2021-04-01
[InstanceEdit:9768818] D'Eustachio, Peter, 2022-03-14
[InstanceEdit:9773653] D'Eustachio, Peter, 2022-05-09
[InstanceEdit:9773910] D'Eustachio, Peter, 2022-05-11
representedPathway[Pathway:75205] Dissolution of Fibrin Clot [Homo sapiens]
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points="148 438" /> </Catalysts> <Properties> <displayName>plasminogen:histidine-rich glycoprotein -&gt; plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="53" reactomeId="158784" points="1259 211, 1260 211, 1158 460" position="1260 211" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="86" points="1322 96" /> <Input id="79" points="1001 211" /> </Inputs> <Outputs> <Output id="84" /> </Outputs> <Properties> <displayName>crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -&gt; crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="56" reactomeId="159001" points="148 679, 148 714, 148 765" position="148 714" lineWidth="1.0"> <Inputs> <Input id="47" points="92 494, 23 522, 23 661" /> <Input id="78" points="229 670" /> </Inputs> <Outputs> <Output id="85" /> </Outputs> <Catalysts> <Catalyst id="92" points="121 714" /> </Catalysts> <Properties> <displayName>urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -&gt; PAI-2:urokinase plasminogen activator (two-chain):uPAR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="59" reactomeId="158893" points="547 424, 547 496, 547 532" position="547 496" lineWidth="1.0"> <Inputs> <Input id="57" points="620 397" /> <Input id="52" points="492 448" /> </Inputs> <Outputs> <Output id="49" /> </Outputs> <Catalysts> <Catalyst id="52" points="495 477" /> </Catalysts> <Properties> <displayName>alpha-2-antiplasmin + plasmin -&gt; alpha-2-antiplasmin:plasmin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="60" reactomeId="158982" points="148 317, 148 281, 279 280" position="148 281" lineWidth="1.0"> <Inputs> <Input id="72" /> </Inputs> <Outputs> <Output id="57" points="629 374, 455 279" /> <Output id="61" points="353 313" /> </Outputs> <Catalysts> <Catalyst id="76" points="147 219" /> </Catalysts> <Properties> <displayName>plasminogen:histidine-rich glycoprotein -&gt; plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="63" reactomeId="158800" points="661 684, 661 733, 661 789" position="661 733" lineWidth="1.0"> <Inputs> <Input id="66" points="932 603" /> <Input id="77" points="738 629" /> </Inputs> <Outputs> <Output id="46" /> </Outputs> <Catalysts> <Catalyst id="93" points="710 734" /> </Catalysts> <Properties> <displayName>fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -&gt; fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="64" reactomeId="159005" points="149 520, 149 545, 149 590" position="149 545" lineWidth="1.0"> <Inputs> <Input id="47" points="149 494" /> <Input id="77" points="713 614, 435 614, 258 520" /> </Inputs> <Outputs> <Output id="58" /> </Outputs> <Catalysts> <Catalyst id="95" points="125 545" /> </Catalysts> <Properties> <displayName>urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -&gt; PAI-1:urokinase plasminogen activator (two-chain):uPAR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="65" reactomeId="158747" points="934 247, 940 388, 989 550" position="940 388" lineWidth="1.0"> <Inputs> <Input id="79" /> </Inputs> <Outputs> <Output id="66" /> </Outputs> <Catalysts> <Catalyst id="57" points="678 388" /> </Catalysts> <Properties> <displayName>crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -&gt; crosslinked fibrin multimer:tissue plasminogen activator (two-chain)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="70" reactomeId="158959" points="145 113, 146 114, 146 177" position="146 114" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="54" points="241 95" /> <Input id="55" points="145 77" /> </Inputs> <Outputs> <Output id="76" /> </Outputs> <Properties> <displayName>urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -&gt; urokinase plasminogen activator:uPAR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="71" reactomeId="158750" points="1073 490, 999 478, 999 398, 968 319" position="999 398" lineWidth="1.0"> <Inputs> <Input id="84" /> </Inputs> <Outputs> <Output id="57" points="678 382" /> <Output id="79" points="943 247" /> </Outputs> <Catalysts> <Catalyst id="84" points="1114 460, 1067 397" /> </Catalysts> <Activators> <Activator id="96" points="1030 371" /> </Activators> <Properties> <displayName>crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -&gt; crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="73" reactomeId="158942" points="128 219, 84 259, 84 410, 119 438" position="84 259" lineWidth="1.0"> <Inputs> <Input id="76" /> </Inputs> <Outputs> <Output id="47" /> </Outputs> <Catalysts> <Catalyst id="57" points="640 374, 540 254" /> </Catalysts> <Properties> <displayName>urokinase plasminogen activator (one-chain):uPAR -&gt; urokinase plasminogen activator (two-chain):uPAR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="74" reactomeId="158795" points="864 682, 864 736, 864 790" position="864 736" lineWidth="1.0"> <Inputs> <Input id="77" points="771 629" /> <Input id="79" points="928 247" /> </Inputs> <Outputs> <Output id="68" /> </Outputs> <Catalysts> <Catalyst id="93" points="812 735" /> </Catalysts> <Properties> <displayName>fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -&gt; fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="75" reactomeId="158941" points="325 234, 326 233, 182 317" position="326 233" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="86" points="1360 62, 1449 25, 526 25" /> <Input id="61" points="370 308" /> </Inputs> <Outputs> <Output id="72" /> </Outputs> <Activators> <Activator id="48" points="309 186" /> </Activators> <Properties> <displayName>plasminogen + histidine-rich glycoprotein -&gt; plasminogen:histidine-rich glycoprotein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="80" reactomeId="158766" points="639 213, 584 212, 584 144" position="584 212" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="67" /> </Inputs> <Outputs> <Output id="137" /> </Outputs> <Catalysts> <Catalyst id="57" points="644 374" /> </Catalysts> <Properties> <displayName>fibrin multimer, crosslinked -&gt; fibrin digestion products (plasmin)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="87" reactomeId="158756" points="1209 644, 1208 715, 1208 769" position="1208 715" lineWidth="1.0"> <Inputs> <Input id="66" points="1067 603" /> <Input id="86" points="1327 96" /> </Inputs> <Outputs> <Output id="82" /> </Outputs> <Properties> <displayName>crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -&gt; crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="88" reactomeId="158781" points="807 214, 805 212, 866 212" position="805 212" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="67" points="744 214" /> <Input id="62" points="756 159" /> </Inputs> <Outputs> <Output id="79" /> </Outputs> <Properties> <displayName>crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -&gt; crosslinked fibrin multimer:tissue plasminogen activator (one-chain)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="89" reactomeId="158722" points="1418 131, 1427 161, 1412 200" position="1427 161" lineWidth="1.0"> <Inputs> <Input id="81" points="1441 91" /> <Input id="86" points="1353 96" /> </Inputs> <Outputs> <Output id="44" /> </Outputs> <Properties> <displayName>histidine-rich glycoprotein + plasminogen &lt;-&gt; histidine-rich glycoprotein:plasminogen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="90" reactomeId="158744" points="1138 805, 999 793, 999 733, 999 691" position="999 733" lineWidth="1.0"> <Inputs> <Input id="82" /> </Inputs> <Outputs> <Output id="57" points="661 402" /> <Output id="66" points="999 620" /> </Outputs> <Catalysts> <Catalyst id="82" points="1143 769, 1076 732" /> </Catalysts> <Properties> <displayName>crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -&gt; crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="130" reactomeId="9724753" points="1138 340, 1138 339, 1094 309" position="1138 339" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="84" points="1141 460" /> <Input id="131" points="1174 271" /> </Inputs> <Outputs> <Output id="132" /> </Outputs> <Properties> <displayName>PLG(20-810) binds anti-fibrinolytics</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="134" reactomeId="9724745" points="1327 434, 1327 434, 1339 378" position="1327 434" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="135" points="1383 482" /> <Input id="84" points="1213 477" /> </Inputs> <Outputs> <Output id="136" /> </Outputs> <Properties> <displayName>PLG(20-810) binds aprotinin</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Dissolution of Fibrin Clot (427162)