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Details on Person The eye-specific diacylglycerol (DAG) kinase, retinal degene...

Class:IdSummation:426643
_displayNameThe eye-specific diacylglycerol (DAG) kinase, retinal degene...
_timestamp2010-11-12 15:22:57
created[InstanceEdit:426680] Williams, MG, 2009-06-17
modified[InstanceEdit:1014206] Williams, MG, 2010-11-12
textThe eye-specific diacylglycerol (DAG) kinase, retinal degeneration A (RDGA) protein phosphorylates DAG to produce phosphatidic acid (PA). DAG is a key entity in events involving proteins in the plasma membrane of the rhabdomere. However, it is also acted on by proteins stationed in the subrhabdomeral cisternae e.g. RDGA, LAZA (PA phosphatase), INAE (DAG lipase). The subrhabdomeral cisternae is about 10nm from the rhabdomere membrane. It is not yet clear how DAG in the rhabdomere membrane gets to interact with RDGA in the subrhabdomeral cisternae. Perhaps there is an undiscovered transport protein that takes DAG from the rhabdomere to the subrhabdomeral cisternae.
(summation)[Reaction:426685] RDGA kinase phosphorylates DAG [Drosophila melanogaster]
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