Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
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Details on Person RISCs containing Argonaute-1 (AGO1, EIF2C1), AGO3 (EIF2C3), ...
| Class:Id | Summation:426519 |
|---|---|
| _displayName | RISCs containing Argonaute-1 (AGO1, EIF2C1), AGO3 (EIF2C3), ... |
| _timestamp | 2013-06-01 09:35:52 |
| created | [InstanceEdit:426518] May, B, 2009-06-16 |
| modified | [InstanceEdit:426527] May, B, 2009-06-16 [InstanceEdit:427820] May, B, 2009-06-26 [InstanceEdit:432324] May, B, 2009-08-13 [InstanceEdit:3656297] May, B, 2013-06-01 |
| text | RISCs containing Argonaute-1 (AGO1, EIF2C1), AGO3 (EIF2C3), and AGO4 (EIF2C4) bind to target RNAs by base-pairing between the target RNA and the guide RNA of the RISC. AGO1,3,4 do not possess ribonuclease activity therefore exact matches between the guide and the target do not result in cleavage of the target. Rather, the effect of binding is inhibition of translation followed by decay of the target RNA. Argonaute proteins have been shown to interact with ribosomal proteins and with components of processing bodies (P-bodies) where RNA degradation occurs. Direct interaction between AGO and a TNRC6 protein is required for inhibition of translation and targeting to P-bodies in vivo. |
| (summation) | [Reaction:426522] Nonendonucleolytic RISC binds exactly matching target RNAs [Homo sapiens] |
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No pathways have been reviewed or authored by RISCs containing Argonaute-1 (AGO1, EIF2C1), AGO3 (EIF2C3), ... (426519)
