Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
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Details on Person RISCs can bind target RNAs that do not exactly match the gui...
| Class:Id | Summation:426513 |
|---|---|
| _displayName | RISCs can bind target RNAs that do not exactly match the gui... |
| _timestamp | 2015-07-30 18:33:48 |
| created | [InstanceEdit:426518] May, B, 2009-06-16 |
| modified | [InstanceEdit:426527] May, B, 2009-06-16 [InstanceEdit:427819] May, B, 2009-06-26 [InstanceEdit:432324] May, B, 2009-08-13 [InstanceEdit:3656297] May, B, 2013-06-01 [InstanceEdit:6789419] May, Bruce, 2015-07-30 |
| text | RISCs can bind target RNAs that do not exactly match the guide RNA carried by an Argonaute. Binding is especially dependent on base-pairing between the target RNA and the eight 5' nucleotides of the guide RNA (miRNA or siRNA). After binding, Argonaute-1 (AGO1, EIF2C1), AGO3 (EIF2C3), and AGO4 (EIF2C4) are incapable of cleavage in all cases. AGO2 is capable of cleaving the target RNA but not if mismatches exist in the middle of the guide (centered about 10 nucloetides from the 5' end of the guide RNA). In the absence of cleavage the target RNA remains bound by the RISC, which inhibits translation of the target RNA and causes the RNA to enter the decay pathway. In vivo, inhibition of translation requires interaction of AGO with a TNRC6 protein and MOV10. The phosphoinositide-3 kinase/mTOR pathway increases expression of GW182, a TNRC6 protein, which increases the portion of AGO:miRNA in high molecular weight complexes with mRNA. |
| (summation) | [Reaction:426489] RISC binds inexactly matching target RNAs [Homo sapiens] |
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No pathways have been reviewed or authored by RISCs can bind target RNAs that do not exactly match the gui... (426513)
