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Details on Person RISC binds inexactly matching target RNAs

Class:Id	Reaction:426489
_displayName	RISC binds inexactly matching target RNAs
_doRelease	TRUE
_timestamp	2017-11-18 10:04:25
authored	[InstanceEdit:426442] May, B, 2009-06-10
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:426518] May, B, 2009-06-16
edited	[InstanceEdit:426442] May, B, 2009-06-10
input	[OtherEntity:426515] RNA (inexact match) [cytosol] [DefinedSet:427783] RISC [cytosol] [Homo sapiens] [DefinedSet:427775] TNRC6 (GW182) [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:426507] Molecular basis for target RNA recognition and cleavage by human RISC [LiteratureReference:426498] Evidence that microRNAs are associated with translating messenger RNAs in human cells [LiteratureReference:427766] Functional Dissection of Human TNRC6, GW182-related, Family of proteins [LiteratureReference:427779] Mammalian GW182 contains multiple Argonaute-binding sites and functions in microRNA-mediated translational repression [LiteratureReference:427785] Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs [LiteratureReference:427768] The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins [LiteratureReference:427826] Identification of novel argonaute-associated proteins [LiteratureReference:432327] Specificity of microRNA target selection in translational repression [LiteratureReference:432331] A role for the P-body component GW182 in microRNA function [LiteratureReference:561203] Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance [LiteratureReference:5600683] Structural features of Argonaute-GW182 protein interactions [LiteratureReference:6789369] Human Argonaute 2 Has Diverse Reaction Pathways on Target RNAs [LiteratureReference:6789410] In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA [LiteratureReference:6789376] Structural basis for microRNA targeting [LiteratureReference:9029454] Multivalent Recruitment of Human Argonaute by GW182
modified	[InstanceEdit:426527] May, B, 2009-06-16 [InstanceEdit:427796] May, B, 2009-06-26 [InstanceEdit:427828] May, B, 2009-06-26 [InstanceEdit:432324] May, B, 2009-08-13 [InstanceEdit:432334] May, B, 2009-08-13 [InstanceEdit:541415] May, B, 2010-03-10 [InstanceEdit:561211] May, B, 2010-03-31 [InstanceEdit:629635] May, B, 2010-04-28 [InstanceEdit:772520] May, B, 2010-05-21 [InstanceEdit:847698] May, B, 2010-05-30 [InstanceEdit:1011169] May, B, 2010-11-11 [InstanceEdit:1082223] May, B, 2010-11-29 [InstanceEdit:1216459] May, B, 2011-02-14 [InstanceEdit:1221617] May, B, 2011-02-25 [InstanceEdit:2106631] May, B, 2012-02-10 [InstanceEdit:2106633] May, B, 2012-02-10 [InstanceEdit:5251727] May, B, 2014-02-05 [InstanceEdit:5600694] May, Bruce, 2014-06-13 [InstanceEdit:6789419] May, Bruce, 2015-07-30 [InstanceEdit:9023923] May, Bruce, 2017-09-29 [InstanceEdit:9029460] May, Bruce, 2017-11-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RISC binds inexactly matching target RNAs
output	[Complex:426501] TNRC6:RISC:Target RNA (inexact match) [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:210805] Removal of miRNA passenger strand [Homo sapiens] [BlackBoxEvent:2106614] Duplex miRNA is loaded into Argonaute [Homo sapiens] [Reaction:9023909] C3PO hydrolyzes cleaved passenger strand [Homo sapiens] [BlackBoxEvent:2106625] Duplex siRNA is loaded into Argonaute [Homo sapiens]
releaseDate	2012-03-13
reviewed	[InstanceEdit:2106616] Tomari, Y, 2012-02-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2158269] R-HSA-426489.5
summation	[Summation:426513] RISCs can bind target RNAs that do not exactly match the gui...
(hasEvent)	[Pathway:426496] Post-transcriptional silencing by small RNAs [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780135] Update Tracker - [Reaction:426489] RISC binds inexactly matching target RNAs - v64:[addLiteratureReference] [_UpdateTracker:9784176] Update Tracker - [Reaction:426489] RISC binds inexactly matching target RNAs - v54:[addLiteratureReference, modifyText] [_UpdateTracker:9786004] Update Tracker - [Reaction:426489] RISC binds inexactly matching target RNAs - v50:[addLiteratureReference] [_UpdateTracker:9786982] Update Tracker - [Reaction:426489] RISC binds inexactly matching target RNAs - v46:[modifyText]
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