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Details on Person Double stranded RNA binds the RISC loading complex and DICER...
| Class:Id | Summation:426458 |
|---|---|
| _displayName | Double stranded RNA binds the RISC loading complex and DICER... |
| _timestamp | 2015-07-29 21:37:42 |
| created | [InstanceEdit:426474] May, B, 2009-06-16 |
| modified | [InstanceEdit:426527] May, B, 2009-06-16 [InstanceEdit:432662] May, B, 2009-08-14 [InstanceEdit:629632] May, B, 2010-04-28 [InstanceEdit:6789294] May, Bruce, 2015-07-29 |
| text | Double stranded RNA binds the RISC loading complex and DICER1, an RNase III component of the complex, cleaves double-stranded RNAs to yield short double-stranded RNAs of 21-25 nucleotides, duplex siRNAs (small interfering RNAs). SiRNAs are similar to microRNAs (miRNAs) in their final structure but differ from miRNAs in their source: siRNAs are produced from long double stranded RNAs that originate from viruses, transposable elements, centromeric repeats and other repetitive structures. The RLC as originally characterized contains DICER1, AGO2, and TARBP2 (TRBP). Alternative RLCs appear to contain other Argonaute proteins (AGO1, AGO3, AGO4) rather than AGO2 and PRKRA rather than TARBP2. Diffusion activity of TARBP2 and PRKRA along duplex RNA may enhance processing by DICER1. |
| (summation) | [Reaction:426464] Dicer cleaves double-stranded RNA to yield double-stranded siRNA [Homo sapiens] |
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No pathways have been reviewed or authored by Double stranded RNA binds the RISC loading complex and DICER... (426458)
