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Details on Person SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region

Class:Id	Reaction:426155
_displayName	SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region
_doRelease	TRUE
_timestamp	2025-08-13 17:59:51
authored	[InstanceEdit:426114] Jassal, Bijay, 2009-06-12
catalystActivity	[CatalystActivity:426138] potassium:chloride symporter activity of SLC12A4,5,6,7 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:426114] Jassal, Bijay, 2009-06-12
crossReference	[DatabaseIdentifier:9959216] RHEA:72428
edited	[InstanceEdit:426114] Jassal, Bijay, 2009-06-12
input	[SimpleEntity:352022] Cl- [cytosol] [SimpleEntity:29804] K+ [cytosol]
literatureReference	[LiteratureReference:426137] Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family [LiteratureReference:426145] Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter [LiteratureReference:426112] Molecular cloning and functional characterization of KCC3, a new K-Cl cotransporter [LiteratureReference:426162] The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum [LiteratureReference:426152] Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family
modified	[InstanceEdit:426169] Jassal, Bijay, 2009-06-12 [InstanceEdit:433652] Jassal, Bijay, 2009-08-24 [InstanceEdit:5623793] Jassal, Bijay, 2014-09-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9959217] Stephan, Ralf, 2025-06-27 [InstanceEdit:9963189] Stephan, Ralf, 2025-08-13
name	SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region K+/Cl- cotransport
negativePrecedingEvent	[NegativePrecedingEvent:9963187] Futile Cycle: SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol
output	[SimpleEntity:188972] Cl- [extracellular region] [SimpleEntity:74126] K+ [extracellular region]
releaseDate	2009-09-30
reviewed	[InstanceEdit:433651] He, L, 2009-08-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105920] R-HSA-426155.3
summation	[Summation:426080] K+/Cl- cotransport is implicated not only in regulatory volu...
(hasEvent)	[Pathway:426117] Cation-coupled Chloride cotransporters [Homo sapiens]
(normalReaction)	[FailedReaction:5623806] Defective SLC12A6 does not cotransport K+, Cl- from cytosol to extracellular region [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9963172] Futile Cycle: SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region
(updatedInstance)	[_UpdateTracker:9789431] Update Tracker - [Reaction:426155] SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region - v38:[modifyText]
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