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Details on Person SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol

Class:Id	Reaction:426130
_displayName	SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol
_doRelease	TRUE
_timestamp	2025-06-27 08:12:35
authored	[InstanceEdit:426114] Jassal, Bijay, 2009-06-12
catalystActivity	[CatalystActivity:426160] sodium:chloride symporter activity of SLC12A3 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:426114] Jassal, Bijay, 2009-06-12
crossReference	[DatabaseIdentifier:9959218] RHEA:73888
edited	[InstanceEdit:426114] Jassal, Bijay, 2009-06-12
input	[SimpleEntity:188972] Cl- [extracellular region] [SimpleEntity:74113] Na+ [extracellular region]
literatureReference	[LiteratureReference:426144] Molecular cloning, expression pattern, and chromosomal localization of the human Na-Cl thiazide-sensitive cotransporter (SLC12A3) [LiteratureReference:426108] Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter
modified	[InstanceEdit:426169] Jassal, Bijay, 2009-06-12 [InstanceEdit:433652] Jassal, Bijay, 2009-08-24 [InstanceEdit:5623756] Jassal, Bijay, 2014-09-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9959217] Stephan, Ralf, 2025-06-27
name	SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol Na+/Cl- cotransport
output	[SimpleEntity:352022] Cl- [cytosol] [SimpleEntity:83910] Na+ [cytosol]
releaseDate	2009-09-30
reviewed	[InstanceEdit:433651] He, L, 2009-08-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104746] R-HSA-426130.3
summation	[Summation:426098] The SLC12A3 gene encodes for the Thiazide-sensitive sodium-c...
(hasEvent)	[Pathway:426117] Cation-coupled Chloride cotransporters [Homo sapiens]
(normalReaction)	[FailedReaction:5623705] Defective SLC12A3 does not cotransport Cl-, Na+ from extracellular region to cytosol [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785911] Update Tracker - [Reaction:426130] SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol - v51:[modifyText]
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