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Details on Person 2-AG hydrolysis to arachidonate by MAGL

Class:Id	Reaction:426043
_displayName	2-AG hydrolysis to arachidonate by MAGL
_doRelease	TRUE
_timestamp	2010-12-02 14:40:04
authored	[InstanceEdit:426042] Jupe, S, 2009-06-11
catalystActivity	[CatalystActivity:426275] monoacylglycerol lipase activity of MGLL [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:426042] Jupe, S, 2009-06-11
edited	[InstanceEdit:435382] Jupe, S, 2009-09-09
input	[SimpleEntity:426030] 2AG [plasma membrane] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:426051] Release of arachidonate from diglyceride in human platelets requires the sequential action of a diglyceride lipase and a monoglyceride lipase [LiteratureReference:426418] A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol
modified	[InstanceEdit:426435] Jupe, S, 2009-06-16 [InstanceEdit:430374] Jupe, S, 2009-08-07 [InstanceEdit:435190] Jupe, S, 2009-09-07 [InstanceEdit:435226] Jupe, S, 2009-09-08 [InstanceEdit:435381] Jupe, S, 2009-09-09 [InstanceEdit:975967] Jassal, Bijay, 2010-10-11 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	2-AG hydrolysis to arachidonate by MAGL
output	[SimpleEntity:422506] AA [plasma membrane] [SimpleEntity:76116] Glycerol [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:426032] DAG is metabolized by DAGL to 2-AG [Homo sapiens] [Reaction:114688] PLC-beta hydrolyses PIP2 to DAG and IP3 [Homo sapiens] [Reaction:398193] PLC beta-mediated PIP2 hydrolysis [Homo sapiens] [Reaction:114689] PLC gamma 2-mediated PIP2 hydrolysis [Homo sapiens]
releaseDate	2009-09-30
reviewed	[InstanceEdit:435013] Akkerman, JW, 2009-09-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105592] R-HSA-426043.2
summation	[Summation:426423] Monoacylglycerol lipase (MAGL) is a key enzyme in the hydrol...
(hasEvent)	[Pathway:426048] Arachidonate production from DAG [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790088] Update Tracker - [Reaction:426043] 2-AG hydrolysis to arachidonate by MAGL - v35:[addInput, addOutput]
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No pathways have been reviewed or authored by 2-AG hydrolysis to arachidonate by MAGL (426043)