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Details on Person SLC9A6,7 exchange Na+ for H+ across the early endosome membrane

Class:Id	Reaction:425983
_displayName	SLC9A6,7 exchange Na+ for H+ across the early endosome membrane
_doRelease	TRUE
_timestamp	2025-06-21 08:25:15
authored	[InstanceEdit:425976] Jassal, Bijay, 2009-06-11
catalystActivity	[CatalystActivity:426008] sodium:proton antiporter activity of SLC9A6,7 [early endosome membrane]
compartment	[Compartment:171062] early endosome membrane
created	[InstanceEdit:425976] Jassal, Bijay, 2009-06-11
crossReference	[DatabaseIdentifier:9958514] RHEA:29421
edited	[InstanceEdit:425976] Jassal, Bijay, 2009-06-11
input	[SimpleEntity:83910] Na+ [cytosol] [SimpleEntity:425978] H+ [early endosome lumen]
literatureReference	[LiteratureReference:426000] Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria [LiteratureReference:425970] Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation
modified	[InstanceEdit:426018] Jassal, Bijay, 2009-06-11 [InstanceEdit:433652] Jassal, Bijay, 2009-08-24 [InstanceEdit:5661045] Jassal, Bijay, 2015-01-08 [InstanceEdit:5661189] Jassal, Bijay, 2015-01-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9958513] Stephan, Ralf, 2025-06-21
name	SLC9A6,7 exchange Na+ for H+ across the early endosome membrane Na+/H+ exchanger transport (at early endosome membrane)
output	[SimpleEntity:70106] H+ [cytosol] [SimpleEntity:425971] Na+ [early endosome lumen]
releaseDate	2009-09-30
reviewed	[InstanceEdit:433651] He, L, 2009-08-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104276] R-HSA-425983.3
summation	[Summation:425979] NHE6 (SLC9A6) (Brett CL et al, 2002; Nakamura N et al, 2005)...
(hasEvent)	[Pathway:425986] Sodium/Proton exchangers [Homo sapiens]
(normalReaction)	[FailedReaction:5661039] Defective SLC9A6 does not exchange Na+ for H+ across the early endosome membrane [Homo sapiens]
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No pathways have been reviewed or authored by SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (425983)