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Details on Person SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+

Class:Id	Reaction:425678
_displayName	SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+
_doRelease	TRUE
_timestamp	2025-06-20 15:15:58
authored	[InstanceEdit:425676] Jassal, Bijay, 2009-06-05
catalystActivity	[CatalystActivity:425670] calcium, potassium:sodium antiporter activity of SLC24A1-4 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:425676] Jassal, Bijay, 2009-06-05
crossReference	[DatabaseIdentifier:9958467] RHEA:69969
edited	[InstanceEdit:425676] Jassal, Bijay, 2009-06-05
input	[SimpleEntity:74113] Na+ [extracellular region] [SimpleEntity:74113] Na+ [extracellular region] [SimpleEntity:74113] Na+ [extracellular region] [SimpleEntity:74113] Na+ [extracellular region] [SimpleEntity:74016] Ca2+ [cytosol] [SimpleEntity:29804] K+ [cytosol]
literatureReference	[LiteratureReference:425683] Molecular cloning and functional expression of the potassium-dependent sodium-calcium exchanger from human and chicken retinal cone photoreceptors [LiteratureReference:425698] Chromosomal localization and genomic organization of the human retinal rod Na-Ca+K exchanger [LiteratureReference:425709] Molecular cloning of a third member of the potassium-dependent sodium-calcium exchanger gene family, NCKX3 [LiteratureReference:425726] Molecular cloning of a fourth member of the potassium-dependent sodium-calcium exchanger gene family, NCKX4 [LiteratureReference:425727] SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans
modified	[InstanceEdit:425696] Jassal, Bijay, 2009-06-05 [InstanceEdit:433652] Jassal, Bijay, 2009-08-24 [InstanceEdit:5625839] Jassal, Bijay, 2014-10-08 [InstanceEdit:5626309] Jassal, Bijay, 2014-10-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9958464] Stephan, Ralf, 2025-06-20
name	SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+
output	[SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74126] K+ [extracellular region] [SimpleEntity:83910] Na+ [cytosol] [SimpleEntity:83910] Na+ [cytosol] [SimpleEntity:83910] Na+ [cytosol] [SimpleEntity:83910] Na+ [cytosol]
releaseDate	2009-09-30
reviewed	[InstanceEdit:433651] He, L, 2009-08-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105905] R-HSA-425678.3
summation	[Summation:425653] The five members of the NCKX (SLC24) family are all able to ...
(hasEvent)	[Pathway:425561] Sodium/Calcium exchangers [Homo sapiens]
(normalReaction)	[FailedReaction:5626270] Defective SLC24A4 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+ [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785821] Update Tracker - [Reaction:425678] SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ - v51:[modifyText]
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