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Details on Person Na+-driven Cl-/HCO3- exchanger transport

Class:Id	Reaction:425577
_displayName	Na+-driven Cl-/HCO3- exchanger transport
_doRelease	TRUE
_timestamp	2025-08-13 17:58:33
authored	[InstanceEdit:425571] Jassal, Bijay, 2009-06-05
catalystActivity	[CatalystActivity:425598] solute:inorganic anion antiporter activity of Na+-driven Cl-/HCO3- exchanger proteins [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:425571] Jassal, Bijay, 2009-06-05
edited	[InstanceEdit:425571] Jassal, Bijay, 2009-06-05
input	[SimpleEntity:352022] Cl- [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:425425] HCO3- [extracellular region] [SimpleEntity:74113] Na+ [extracellular region]
literatureReference	[LiteratureReference:425596] Characterization of human SLC4A10 as an electroneutral Na/HCO3 cotransporter (NBCn2) with Cl- self-exchange activity [LiteratureReference:425559] Characterization of Na+/HCO-3 cotransporter isoform NBC-3
modified	[InstanceEdit:425676] Jassal, Bijay, 2009-06-05 [InstanceEdit:433652] Jassal, Bijay, 2009-08-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9963189] Stephan, Ralf, 2025-08-13
name	Na+-driven Cl-/HCO3- exchanger transport
output	[SimpleEntity:188972] Cl- [extracellular region] [SimpleEntity:351626] H+ [extracellular region] [SimpleEntity:111627] HCO3- [cytosol] [SimpleEntity:83910] Na+ [cytosol]
precedingEvent	[Reaction:427555] SLC26A1,2 cotransport SO4(2-), anion from extracellular region to cytosol [Homo sapiens] [Reaction:425577] Na+-driven Cl-/HCO3- exchanger transport [Homo sapiens] [Reaction:427666] SLC26A3,6 exchange Cl- for HCO3- [Homo sapiens] [Reaction:425577] Na+-driven Cl-/HCO3- exchanger transport [Homo sapiens] [Reaction:425482] SLC4A1,2,3 exchanges HCO3- for Cl- [Homo sapiens] [Reaction:425577] Na+-driven Cl-/HCO3- exchanger transport [Homo sapiens] [Reaction:8878664] SLC4A4 cotransports Na+ with 3HCO3- [Homo sapiens] [Reaction:425577] Na+-driven Cl-/HCO3- exchanger transport [Homo sapiens] [Reaction:425483] SLC4A5,7,9 cotransport Na+ with 3HCO3- [Homo sapiens] [Reaction:425577] Na+-driven Cl-/HCO3- exchanger transport [Homo sapiens]
releaseDate	2009-09-30
reviewed	[InstanceEdit:433651] He, L, 2009-08-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105473] R-HSA-425577.3
summation	[Summation:425565] Two genes encode Na+-dependent Cl-/HCO3- exchangers; SLC4A8 ...
(hasEvent)	[Pathway:425381] Bicarbonate transporters [Homo sapiens]
(precedingEvent)	[Reaction:425482] SLC4A1,2,3 exchanges HCO3- for Cl- [Homo sapiens] [Reaction:425483] SLC4A5,7,9 cotransport Na+ with 3HCO3- [Homo sapiens] [Reaction:427555] SLC26A1,2 cotransport SO4(2-), anion from extracellular region to cytosol [Homo sapiens] [Reaction:427666] SLC26A3,6 exchange Cl- for HCO3- [Homo sapiens] [Reaction:8878664] SLC4A4 cotransports Na+ with 3HCO3- [Homo sapiens]
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No pathways have been reviewed or authored by Na+-driven Cl-/HCO3- exchanger transport (425577)